肺转移瘤体部X刀立体定向放射治疗30例分析  

Analysis of 30 cases with lung metastases treated by fractionated stereotactic radiotherapy

作　　者：于金明[1] 郭守芳[1] 李建彬[1] 尹勇[1] 芦洁[1] 王亚彬[1] 

机构地区：[1]山东省肿瘤防治研究所,250117

出　　处：《临床肺科杂志》2002年第1期21-23,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的　探讨体部 X刀立体定向放射治疗转移瘤的方法和疗效。方法　采用 CT定位 ,XKB- 1型体部 X刀立体定向放射治疗系统立体定向放疗肺转移瘤 30例 ,共计 78个病灶。病灶大小 0 .4cm～ 5 .4cm,<3cm者 5 6个 ,3cm～ 5 cm者 2 0个 ,>5 cm者2个。辐射源为 6 MVX线。单次照射剂量 3Gy～ 12 Gy,总剂量 2 0 Gy～ 48Gy。结果　肿瘤消失 12灶 (15 .4% ) ,缩小 49灶 (6 2 .8% ) ,总有效率 78.2 % ;病灶 <3cm者 ,有效率为 87.5 % ,明显高于肿瘤≥ 3cm者 (P<0 .0 1;总剂量 2 0 Gy～ 30 Gy者 ,有效率为 88% ;总剂量≤ 30 Gy组中 ,肿瘤 <3cm者的有效率高于肿瘤≥ 3cm者 (P<0 .0 1,而总剂量 >30 Gy组两者无显著差异 (P>0 .0 5 )。全组病人的1、2、3年生存率分别为 6 3.3% (19/ 30 )、34 .8% (14/ 30 )和 2 1.4% (4 / 14)。结论　体部 X刀立体定向放射治疗是治疗肺转移瘤的有效方法 ,其近期疗效与转移灶大小与照射剂量相关。Objective To explore the methodsand effects of body x knife fractionated stereotactic radiotherapy in the treatment of lung metastases.Material and Methods From Nov.1996 to Jul.1999,30 cases with lung metastaes were treated by fractionated sterotactic radiotherapy using XKB 1 model body x knife in our hospital.The total number of the metastases were 78.The diameter of the metastases was 0.4～5.4cm,less than 3 cm in 56,3cm～5cm in 20,and more than 5 cm in 2.6MV.X ray was chosen as radiationsource.The dose per fraction was 3Gy～12Gy,and the total prescribed dose was 20Gy～48Gy at the margin of the PTV enveloped by 90%～100% insodose curve.Result Local regression of the metastases were evaluated by CT image or MRI obtained in 3 months after treatment.Complete regression was found in 12 foci(15.4%),partial regression in 49 foci(62.8%),and the overall effective rate was 78.2.The effective rate for the foci with diameter less than 3 cm was 87.5%,and 54.5% equal or more than 3 cm,there was significantly different(P<0.01).Conclusion Body X knife is an effective treatment method,for patients with Lung metratases.

关 键 词：肺转移瘤 放射治疗 立体定向放射治疗 治疗方法 疗效 

分 类 号：R734.2[医药卫生—肿瘤]