血管紧张素Ⅱ受体及其受体拮抗剂研究进展  

Advances in Research of Angiotensin Ⅱ Receptor and It's Antagonists

作　　者：王正荣[1] 张建萍[1] 王浴生[1] 

机构地区：[1]华西医科大学基础医学院,四川,成都,610041

出　　处：《心血管病学进展》2002年第2期69-72,共4页Advances in Cardiovascular Diseases

摘　　要：血管紧张素 (Ang )是肾素 -血管紧张素系统 (RAS)中最为重要的活性激素 ,它在高血压的病理生理中起着重要的作用。Ang 的作用通过细胞表面的 Ang 受体介导 ,根据与不同受体拮抗剂的选择性可将其受体分为两个亚型 :AT1 受体和 AT2受体。已知的 Ang 的生理作用是由 AT1 受体介导的 ,AT2 受体的功能尚不清楚。在临床上主要有两种抑制 RAS活性的药物 :一是血管紧张素转化酶抑制剂 (ACEI) ,它抑制 Ang 的生成 ;二是 AT1 受体拮抗剂 ,它阻断 Ang 相应受体的生理学作用。AT1AngiotensinⅡ(AngⅡ)is the most important hormone in the renin angiotensin system(RAS).It plays an important role in the pathophysiology of hypertension.Angiotensin Ⅱ exerts its effects through specific membrane receptors.Angiotensin Ⅱ receptors can be divided into two subtypes,AT 1 receptor and AT 2 receptor,based on the selectivity for different antagonists.So far,almost all the actions of AngⅡhave been found to be meditated by AT 1 receptor,the function of AT 2 receptor having yet to be established.Two kinds of medicine are applied clinically to inhibit the activity of RAS.One is ACEI(Angiotensin Converting Enzyme Inhibitors)which can inhibit the production of AngⅡ,the other is AT 1 Receptor Antagonists which could block those physiological actions meditated by AngⅡ.The potent clinical application are being under further research.

关 键 词：血管紧张素Ⅱ 肾素-血管紧张素系统 血管紧张素Ⅱ受体 受体拮抗剂 高血压 

分 类 号：R363[医药卫生—病理学]