术前动脉灌注化疗对大肠癌微血管密度的影响  

Effects on micro-vessel density after pre-operative intra-arterial infusion chemotherapy in colorectal cancer

作　　者：林清[1] 李志霞[1] 张立军[1] 张树荣[1] 徐工学[1] 郭连瑞[1] 安大力 

机构地区：[1]首都医科大学附属北京同仁医院普外科,北京100730

出　　处：《中华肿瘤杂志》2002年第1期84-86,共3页Chinese Journal of Oncology

摘　　要：目的　分析评价术前动脉灌注化疗对大肠癌生物学行为的影响 ,并探讨术前动脉灌注化疗对肿瘤细胞影响的作用机制。方法　 2 8例 (同意入组研究 )大肠癌患者随机分成术前动脉灌注化疗组 (12例 )和对照组 (16例 )。术前动脉灌注化疗采用动脉造影技术 ,经肿瘤营养动脉给予 5 Fu10 0 0mg ,表阿霉素 6 0mg ,丝裂霉素 10mg。全部患者均接受手术治疗 ,切除标本分别行常规病理检查及免疫组织化学染色 (Ⅷ因子相关抗原染色 )测定大肠癌组织微血管密度 (MVD)。微血管密度计数采用Weidner方法分别计数癌中心、癌黏膜表面及癌旁组织的微血管数。结果　术前动脉灌注化疗组大肠癌组织中心、癌黏膜表面及癌旁组织的MVD分别为 40 .46± 7.0 6、5 2 .2 7± 18.40和 49.92± 8.15 ;对照组大肠癌组织中心、癌黏膜表面及癌旁组织的MVD分别为 46 .0 9± 12 .2 1、73.44± 2 2 .0 6和5 1.94± 12 .6 4。两组之间癌黏膜表面的MVD值差异有显著性 (P <0 .0 5 ) ,癌旁组织及癌中心组织MVD差异无统计学意义。结论　术前动脉灌注化疗可以降低大肠癌组织黏膜表面的微血管密度。Objective To evaluate the effects of pre-operative intra-arterial infusion chemotherapy on colorectal cancer.Methods Twenty-eight patients with colorectal cancer, treated by surgery from February to October 2000, were divided into two groups randomly. There were 12 patients in group A (pre-operative intra-arterial infusion chemotherapy) and 16 in group B (control). Arterial contrast technique was used in group A, then mitromycin 10 mg, 5-Fu 1 000 mg, epirubicin 60 mg were given through Weidner's way.Results Micro-vessel density in the center, surface of the tumor and adjacent tissue around the tumor were 40.46±7.06, 52.27± 18.40 , 49.92±8.15 in group A, and 46.09±12.21, 73.44±22.06, 51.94±12.64 in group B. Micro-vessel density on the surface in group A was significantly lower than that of group B ( P <0.05), with no significance between the center and the adjacent tissue.Conclusion Pre-operative intra-arterial infusion chemotherapy is able to reduce micro-vessel density on the surface of colorectal tumor.

关 键 词：大肠癌药物疗法 微血管密度 动脉灌注化疗 治疗 术前化疗 

分 类 号：R735.3[医药卫生—肿瘤]