大剂量醛氢叶酸联合氟尿嘧啶为主的化疗方案治疗头颈与消化道癌56例  

Combined high dose leucovorin and 5-fluorouracil continuous infusion for head-neck and digestive tract cancers

作　　者：许德明[1] 陈国权[1] 李声谊[1] 蔡永广[1] 陈焕伟[1] 凌华海[1] 李子庆[1] 

机构地区：[1]广东省农垦中心医院肿瘤内科,湛江524002

出　　处：《中华肿瘤杂志》2002年第1期93-95,共3页Chinese Journal of Oncology

摘　　要：目的　探讨治疗头颈与消化道癌实用有效的化疗方案。方法　采用大剂量醛氢叶酸(HD CF) +5 氟尿嘧啶 (5 Fu)为主的联合化疗方案 ,持续滴注 48h ,治疗头颈与消化道癌 5 6例 ,每例患者平均 3.8个周期 (2～ 6周期 )。结果　全组患者有效率 (CR +PR)为 35 .7% ,临床受益率达 80 .4%。不良反应为外周静脉炎、骨髓抑制、口腔溃疡和恶心呕吐等 ,但多为Ⅰ～Ⅱ度。结论　大剂量醛氢叶酸 +5 氟尿嘧啶为主的联合化疗方案 ,持续滴注 48h ,治疗头颈与消化道癌疗效较满意 ,经济实用 ,值得进一步研究。Objective To evaluate the feasibility of combined high dose leucovorin plus 5-fluorouracil infusion for head-neck and digestive tract cancers.Methods Fifty-six patients with head-neck and digestive tract cancer were treated by combined high dose leucovorin (HD-CF) plus 5-fluorouracil (5-Fu) 48 hour continuous infusion with each patient receiving an average of 3.8 cycles (2-6 cycles). Twenty-five of these 56 patients were untreated and 31 recurrent. Their clinical stages were Ⅱ 4, Ⅲ 13 and Ⅳ 39. Results The over all response rate (CR+PR)was 35.7% and the clinical benefitial response rate was 80.4%. The main side effects were peripheral phlebitis, suppression of bone marrow, oral ulcer, nausea and vomiting of grade Ⅰ to Ⅱ.Conclusion High dose leucovorin plus 5-fluorouracil 48 hour continuous infusion is useful with favorable cost/utility ratio for head-neck and digestive tract cancer patients. Further studies are warranted.

关 键 词：头颈部肿瘤 消化系统肿瘤 药物疗法 醛氢叶酸 氟尿嘧啶治疗 癌 联合化疗 

分 类 号：R735[医药卫生—肿瘤]