食管癌组织中nm23-H1、CD44V6蛋白表达与区域淋巴结转移的关系  

Relation Between nm23-H1,CD44V6 Protein Expression and Local Lymph Node Metastases in Esophageal Carcinoma Tissues

作　　者：王兴武[1] 方晋平[1] 国前[1] 魏玲[1] 郑燕[1] 侯青[1] 

机构地区：[1]山东省肿瘤防治研究院基础研究中心,250117

出　　处：《实用癌症杂志》2002年第1期10-12,共3页The Practical Journal of Cancer

摘　　要：目的　研究食管癌组织中nm 2 3 H 1、CD 44V 6蛋白表达与食管癌区域淋巴结转移的关系。方法　应用流式细胞仪定量分析 5 5例食管癌组织中nm 2 3 H 1、CD 44V 6蛋白的表达 ,同时检测DNA倍体状态。结果　有区域淋巴结转移组nm 2 3 H 1蛋白表达低于无转移组 ,而CD 44V 6蛋白表达高于无转移组 (均P <0 .0 5 ) ;异倍体率与淋巴结转移及nm 2 3 H 1、CD44V 6蛋白表达均无关 (P >0 .0 5 ) ,增殖活性与淋巴结转移及nm 2 3 H 1、CD 44V 6蛋白表达均相关 (P <0 .0 5 )。食管癌组织中nm 2 3 H 1蛋白表达与CD 44V 6蛋白表达无关 (P >0 .0 5 )。结论　nm 2 3和CDObjective To study the relation between nm23 H1,CD44V6 protein expression and local lymph node metastases in esophageal carcinoma.Methods Flow cytometry was used to analyze nm23 H1,CD44V6 protein expression and DNA ploidy in 55 esophageal tumor tissues.Results nm23 H1 protein expression in local lymph node metastatic tumors was lower but CD44V6 protein expression was higher than that in free lymph node metastases group( P <0.05).Aneuploid ratios wasn't related with lymph node metastases and nm23 H1,CD44V6 protein expression ( P >0.05),but cellular proliferation activity had correlations with local lymph node metastases and nm23 H1,CD44V6 protein expression ( P <0.05).There was no relationship between nm23 H1 and CD44V6 protein expression of esophageal carcinoma tissues ( P >0.05).Conclusion These results suggest that nm23 and CD44 genes play an important role in the tumor development and metastases of esophageal carcinoma.The detection of nm23 protein expression and CD44 plus DNA ploidy could improve the objectivity and accuracy of experimental research.

关 键 词：NM23-H1蛋白 CD44V6蛋白 食管癌 淋巴结转移 

分 类 号：R735.1[医药卫生—肿瘤] R733.4[医药卫生—临床医学]