食管小细胞癌的治疗及预后分析  

Treatment and Prognosis for Patients with Small Cell Esophageal Carcinoma

作　　者：王佳玉[1] 屈凤莲[1] 王子平[1] 王金万[1] 

机构地区：[1]中国医学科学院中国协和医科大学肿瘤医院,100021

出　　处：《实用癌症杂志》2002年第1期69-71,共3页The Practical Journal of Cancer

摘　　要：目的　探讨影响食管小细胞癌治疗预后的因素。方法　对 1975年 1月至 1995年 12月收治的 60例食管小细胞癌的病例资料 ,应用SPSS 8.0统计软件中Cox回归函数 ,对其中 44例患者的预后进行多因素分析。结果　 5年随访率为 73 .3 %。局限期患者 1、2、5年生存率分别为 5 1.8%、2 9.6%及 18.5 %。中位生存期为 11个月 ;广泛期患者 1、2、5年生存率分别为 47.6%、17.6%及 0。中位生存期为 10个月。影响局限期和广泛期患者预后的主要因素分别为年龄和治疗手段 (P <0 .0 5 )。结论　肿瘤临床分期及发病年龄是影响食管小细胞癌患者预后的主要因素。对于广泛期患者 。Objective To evaluate the prognostic factors in the patients with small cell esophageal cancer (SCEC).Methods From 1/1975 to 12/1995,the 60 cases of SCEC were studied.A multivariate analysis was performed in 44 patients for the cumulative survival rate by Cox regression in Spass 8.0 software.Results 73.3% patients was followed up over 5 years.In limited stage (LS),the over all cumulative survival rates were 51.8%at 1 year,29.6% at 2 years,and 18.5% at 5 years,the median survival time was 11 months.In extensive stage (ES),the over all cumulative survival rates were 47% at 1 year,17.6% at 2 years,and 0 at 5 years,the median survival time was 10 months.The results showed that the major significant prognostic factor were age in limited stage and treatment in extensive stage( P <0.05) respectively.Conclusion Stage and age are the most important prognostic factors for SCEC.Systemic treatment including chemotherapy is very important to improve the survival rate of the patients with SCEC.

关 键 词：食管小细胞癌 局部治疗 全身治疗 预后分析 中位生存期 治疗 化疗 

分 类 号：R735.1[医药卫生—肿瘤] R730.5[医药卫生—临床医学]