环孢素A联合化疗方案治疗复发、难治性白血病  

CsA ASSDCIATED WITH CHEMOTHERAPY IN THE TREATMENT OF REFRACTORY ACUTE LEUKEMIA

作　　者：王全顺[1] 周绮[1] 于力[1] 达万明[1] 楼方定[1] 

机构地区：[1]解放军总医院,北京100853

出　　处：《白血病．淋巴瘤》2002年第1期18-20,共3页Journal of Leukemia & Lymphoma

摘　　要：目的 :探讨用环孢素 A联合化疗方案治疗复发、难治性白血病的疗效。方法 :18例急性非淋巴细胞白血病患者 ,采用 Cs A+ DA方案治疗 6例 ,Cs A+ MAE方案治疗 12例。结果 :Cs A+DA组完全缓解率为 3 3 %。 Cs A+ MAE组完全缓解率为 5 0 %。两组病例的有效率及完全缓解率经统计学分析没有显著差异 ,P值均大于 0 .5。结论 :环孢素能够逆转难治性白血病的耐药性 ,在难治性白血病的治疗中有一定作用 。Objective:To study the CsA associated with chemotherapy in the treatment of refractory acute myeloblastic leukemia.Methods:18 cases of acute myeloblastic leukemia has treated in the regime of cyclosporin A(CsA) associated with chemotherapy.Results:The ratio of complete remission were separately 33 % and 50 % in the cases treated with CsA+DA and CsA+MAE.The difference between results of two treatment has no statiatic sence.Conclusion:CsA associated with chemotherapy is a effective considerable regimen in treatment of refractory acute myelogenous leukemia.

关 键 词：急性非淋巴细胞白血病 难治性 化疗 环孢素A 治疗 

分 类 号：R733.7[医药卫生—肿瘤]