血浆血管紧张素原在动脉粥样硬化性血栓性脑梗死发病中的变化及意义  

Changes in plasma angiotensinogen concentration in atherosclerotic cerebral infarction and its implication

作　　者：葛剑青[1] 张颖冬[1] 石静萍[1] 方群[1] 周展凤[1] 

机构地区：[1]南京医科大学附属脑科医院神经内科,江苏南京210029

出　　处：《中国危重病急救医学》2002年第1期26-28,共3页Chinese Critical Care Medicine

基　　金：江苏省应用基础研究基金资助项目 ( No.BJ980 92)

摘　　要：目的 :探讨血浆血管紧张素原 (ATG)在动脉粥样硬化性血栓性脑梗死 (ACI)发病中的变化及意义。方法 :对 5 7例 ACI患者和 32例健康对照者以放射免疫法测定血浆 ATG和血管紧张素 (AT )浓度。结果 :ACI患者急性期血浆 ATG浓度为 (194.47± 43.83) ng/ L ,显著高于恢复期〔(16 3.45± 42 .6 4) ng/ L〕及健康对照者〔(15 9.34± 45 .2 4) ng/ L〕;重型者为 (2 36 .91± 48.5 3) ng/ L ,显著高于轻型者〔(173.84± 33.87) ng/ L〕;而血浆 ATG浓度与是否伴高血压以及病变部位无关 ;血浆 ATG浓度变化与 AT 浓度变化呈直线正相关。结论 :脑梗死可致血浆 ATG浓度应激性升高 。Objective:To investigate the changes and clinical implication of plasma angiotensinogen (ATG) concentration in the patients with atherosclerotic cerebral infarction (ACI).Methods:The plasma concentrations of ATG and angiotensinⅡ (ATⅡ) in 57 patients with ACI and 32 healthy controls were measured with radioimmunoassay.Results:The plasma ATG concentrations in the acute phase of ACI patients 〔(194 47±43 83)ng/L〕 were significantly higher than that in the recovery phase 〔(163 45±42 64)ng/L〕 and that in the controls 〔(159 34±45 24)ng/L〕.Also ATG levels were markedly higher 〔(236 91± 48 53)ng/L 〕 in the severe patients than that in the mild patients 〔(173 84±33 87)ng/L〕.There was no correlation between the plasma ATG concentration and concomitant presence of hypertension or the lesion sites.However,the plasma ATG concentration correlated linearly with the plasma ATⅡ concentration.Conclusions:Cerebral infarction can result in an elevated concentration of plasma ATG,which may be related with the degree of ischemic brain lesions.

关 键 词：血栓性脑梗死 脑梗死 动脉粥样硬化性 血管紧张素Ⅱ 血管紧张素原 

分 类 号：R743.33[医药卫生—神经病学与精神病学]