幽门螺杆菌感染致胃粘液细胞膜通透性增高  

The change of cell membrane permeability of mucous cells after Helicobacter pylori infection

作　　者：周琳瑛[1] 梁平[1] 陈丽英[2] 陈莲云[1] 

机构地区：[1]福建医科大学电镜室,350004 [2]福建医科大学病理教研组,350004

出　　处：《福建医药杂志》2001年第6期1-2,共2页Fujian Medical Journal

基　　金：福建省教委科技三项费资助项目;No.K970 36

摘　　要：目的　探讨 Hp感染后胃粘液细胞细胞膜通透性的改变 ,并探讨其临床意义。方法　采用常规 HE、 W- S染色、电镜细胞化学技术观察胃粘液细胞膜通透性 (D/L)的改变 ,并探讨 D/L与 Hp数量、 PMN浸润间的关系。结果　 Hp感染后部分粘液细胞细胞膜的通透性 (D/L)增大 ,且 D/L值与 Hp的数量、PMN浸润程度均呈正相关 (P<0 .0 1 )。结论　 Hp感染后胃粘膜屏障确有减弱或局部破坏 ,这可能是Objective:To study the change of membrane permeability of some mucous cells after Helicobacter pylori(Hp)infection.Methods:Histopathologic techniques such as HE,W S staining,and electron microscopic cytochemistry technique were used to study the changes of gastric mucosa,and to evaluate the relationship between the number of Hp,PMN and the permeability of mucous cells(D/L).Results:Tannic acid staining showed cell membrane permeability of some mucous cells increased,the ratio of D/L correlated with the number of both Hp and PMN(P<0 01).Conclusion:The damage of gastric mucosal barrier after Hp infection is one of the important pathogenectity of Hp related diseases.

关 键 词：幽门螺杆菌 胃粘膜 通透性 HP感染 慢性胃炎 消化性溃疡 

分 类 号：R573[医药卫生—消化系统]