IVP方案与CAP方案治疗115例老年晚期非小细胞肺癌的对比研究  

Comparative Study of IVP and CAP in the treatment of 115 cases with advanced non-small-cell lung cancer in aged

作　　者：陈毅德[1] 林亚乐[1] 姜燕[1] 

机构地区：[1]厦门市第二医院肿瘤科,361002

出　　处：《福建医药杂志》2001年第6期7-9,共3页Fujian Medical Journal

摘　　要：目的　对比 IVP方案与 CAP方案治疗老年晚期非小细胞肺癌的临床疗效、生存期及毒副反应。方法　统计分析用 IVP(异环磷酰胺 ,鬼臼乙叉甙 ,顺铂 )方案及 CAP(环磷酰胺 ,阿霉素 ,顺铂 )方案治疗 1 1 5例老年晚期非小细胞肺癌病例的临床资料。结果　 IVP组有效率为 58.6% ,其中完全缓解 5例 ,中位生存时间 1 1个月 ,1年生存率 31 % ;CAP组有效率为 2 9.8% ,中位生存时间 6.5个月 ,1年生存率 1 4 %。毒副反应主要为骨髓抑制 ,消化道反应及脱发。结论　 IVP方案治疗老年晚期非小细胞肺癌疗效优于 CAP方案 ,毒副反应轻 ,值得作为一线治疗方案进一步推广应用。Objective:To compare the clinical activity,survival and toxicity of IVP and CAP for advanced non small cell cancer(NSCLC)in aged.Methods:The clinical data of 115 cases with advanced NSCLC treated with IVP regimen(IFO+VP-16+PDD,58cases)and CAP regimen(XTX+ADM+PDD,57cases)were analysed.Results:The response rate was 58 6% in patients treated with IVP,and 29 8% in those treated with CAP.The overall median survival time in the IVP group was 11 months,and 6 5 months in the CAP group.The one year survival rate was 31% and 14% respectively.The major toxic reactions in the two groups were tolerable myelo suppression,digestive tract reaction and hair loss.Conclusion:IVP are effective and safe chemotherapy regimen and be used as first line regimen for treatment of advanced NSCLC in aged.

关 键 词：异环磷酰胺 老年 非小细胞肺癌 化学治疗 IVP方案 CAP方案 

分 类 号：R734.2[医药卫生—肿瘤]