舌癌与瘤内血管形成相关性研究  

The relations between intratumor microvessel density and tongue cancer prognosis

作　　者：张乃嵩[1] 宁晓明[2] 武秋敏[1] 贾琛汕[1] 

机构地区：[1]哈尔滨医科大学附属第三医院头颈外科,黑龙江哈尔滨150040 [2]哈尔滨医科大学附属第三医院病理科,黑龙江哈尔滨150040

出　　处：《哈尔滨医科大学学报》2001年第4期269-271,F003,共4页Journal of Harbin Medical University

摘　　要：目的　研究瘤内血管密度 (MD)与舌癌淋巴结转移、复发以及对预后的影响。方法　采用免疫组化SP法FⅧ因子多克隆抗体对 36例舌癌、瘤内血管进行标记分析。结果　颈淋巴结转移组 (19例 )MD31 35± 4 42 ,明显高于无转移组 (17例 )MD15 .12± 5 .34(P <0 .0 1)。随访发现 ,MD高表达组与低表达组颈清术后复发率分别为 6 0 %和12 5 % (P <0 .0 1)。舌原发灶复发 8例MD为 45 .5 7± 6 .2 6 ,比无复发组 2 8例MD2 0 .35± 4.13高二倍多 (P <0 .0 1)。结论　肿瘤内血管形成与舌癌的复发转移密切相关 ,而与病理分级及临床分期无关。因此瘤内MD可作为判定舌癌预后的独立指标。Objective To investigate the relations between intratumor microvessel density and tongue cancer prognosis in 36 patients with tongue cancer.Methods Expression of intratumor microvessel density(MD) was established by immunohistochemical method using a polyclinal antibody of FⅧ on tongue cancer(stage T 1-4 ).Thirty six patients were divided into two groups:cervical lymph node metastasis(19 cases) and no cervical lymph node metastasis(17 cases).Results The expression of MD was higher in the cervical lymph node metastasis(31.35±4.42) than that in the no cervical lymph node metastasis(15.12±5.34)( P <0.01).The recurrence rate of cervical lymph node was 60% in higher expression group(12/20 cases MD≥25.18),while 12.5% in lower expression group (1/16 cases MD<25.18)( P <0.01).The expression of MD was higher in recurrence group of tongue area(8 cases 45.5±6.21) than in no recurrence group of tongue area(28 cases,20.35±4.14)( P <0.01).Conclusion The expression of intratumor MD is related to the metastasis and occurrence of tongue cancer.

关 键 词：舌肿瘤 血管密度 鳞状细胞癌 预后 相关性 MD 

分 类 号：R739.86[医药卫生—肿瘤]