X-刀结合全脑放疗治疗脑转移瘤疗效分析  

Analysis of X-knife combined with whole brain irradiation for brain metastasis

作　　者：韩波[1] 邓晓琴[1] 李瑛[1] 

机构地区：[1]哈尔滨医科大学附属第一医院综合病房,黑龙江哈尔滨150001

出　　处：《哈尔滨医科大学学报》2001年第4期280-282,共3页Journal of Harbin Medical University

摘　　要：目的　分析X 刀结合全脑放疗治疗脑转移瘤的疗效及预后因素。方法　治疗脑转移瘤 43例 ,单发病灶15例 ,多发病灶 2 8例 ,单纯X 刀治疗 11例 ,X 刀结合全脑放疗 32例 ;病灶中心剂量单发者 2 0～ 2 7Gy(平均 2 5 .8Gy) ,多发者 14～ 32Gy(平均 17Gy)。全脑放疗与X 刀治疗间隔 5～ 7日 ,剂量每次 1.8～ 2 .0Gy ,5次 /周。总量 2 4～ 40Gy。结果　全组 1年生存率 5 1.2 % (2 2 / 43) ,中位生存期 11.3个月 ;全脑照射 30～ 35Gy组与 35～ 40Gy组 1年生存率分别为 80 .0 % ,70 .2 % ;疗效与KPS评分、病灶数目、全脑照射剂量、原发灶治疗与否相关。结论　X 刀结合全脑照射能有效缓解症状 ,改善生存质量 。Objective To analyse the effect of X knife combined with whole brain irradiation (WBI) in the treatment of brain metastasis.Methods Forty three patients with brain metastasis were selected,11 of them were treated by X knife alone and 32 of them by X knife with whole brain irradiation(WBI).The prescribed dose was 20～27Gy (average 25.8Gy ) for single tumor and 14～32Gy (average17Gy) for multi-tumors.The WBI dose was 24～40Gy with 1.8～2.0Gy per day.Results The 1 year survival rate was 51.2%(22/43) and median survival period was 11.3 months .The 1 year survival rate in WBI 30 35Gy group and in 35～40Gy group were similar with 80.0%, 72.7 %,respectively. Conclusion X knife with WBI is effective to relief symptoms,improve quality of life for brain metastasis.

关 键 词：脑转移瘤 全脑放射治疗 X-刀 疗效 预后 

分 类 号：R739.41[医药卫生—肿瘤] R730.5[医药卫生—临床医学]