P53蛋白表达与膀胱移行细胞癌临床病理及预后关系的研究  

Relationship between P53 protein expression and clinicopathologic features, prognosis in bladder transitional cell carcinoma

作　　者：王春喜[1] 王立波[1] 候宇川[1] 姚子明 赵忠文[1] 

机构地区：[1]吉林大学第一医院泌尿外科,吉林长春130021

出　　处：《白求恩医科大学学报》2001年第6期614-614,共1页Journal of Norman Bethune University of Medical Science

基　　金：教育部出国留学人员科研启动基金资助课题 (1998- 6 79)

摘　　要：目的 :探讨 P5 3蛋白的异常表达在膀胱移行细胞癌 (TCC)发生、发展中的作用及在预后判断中的价值。方法 :应用抑癌基因 p5 3单克隆抗体 (DAKO- DO- 7)对 15 1例原发 TCC组织进行免疫组织化学染色 ,分析染色结果与临床病理及预后的关系。结果 :随临床分期及病理分级程度的升高 ,P5 3蛋白表达呈升高趋势 ,浸润性 (p T2~ 4 )和高分级 (G3 ) TCC P5 3蛋白表达明显高于浅表性 (p Ta~ 1)和低分级TCC(G1~ 2 )。结论 :TCC的进展可能与 p5 3基因的异常改变密切相关 ,P5 3蛋白异常表达及临床分级可作为TCC预后的判断指标。Objective: To investigate the relationship between P53 protein expression and etiology, development, prognosis in bladder cancers. Methods: Immunohistochemical staining, by monoclonal antibody of P53 protein (DAKO DO 7), was employed in tumor tissues from 102 cases of primary bladder cancer. And the staining results were analized,compared with the clinicopathologic features and prognosis. Results: Our results suggested P53 protein expression was heigher in tumors of heigh clinical and pathological grade, as P53 protein expressions in invasive (pT 2~4 ) and heigh grade(G 3)tumors were significantly heigher than those in superficial(pT a~1 )or low grade (G 1~2 ) tumors. Conclusions: The development of bladder cancer closely correlated with abnormality of p53 gene. The level of P53 protein expression and stage may be used as ideal markers for discriminating the prognosis of bladder cancer.

关 键 词：膀胱移行细胞 P53蛋白 预后 

分 类 号：R737.14[医药卫生—肿瘤]