功能矫形对大鼠翼外肌细胞膜乙酰胆碱受体最大结合容量影响的研究  

The maximun binding changes of the acetylcholine receptor on rat lateral pterygoid muscle after the function mandibular advancement.

作　　者：陈开云[1] 罗颂椒[1] 

机构地区：[1]四川大学华西口腔医学院,四川成都610041

出　　处：《四川医学》2002年第3期244-245,共2页Sichuan Medical Journal

基　　金：国家自然科学基金资助项目 ;编号 :30 1 71 0 2 4

摘　　要：目的　观察功能矫形前伸青春期大鼠下颌后 ,翼外肌细胞膜乙酰胆碱受体 ( n- Ach R)最大结合容量 ( Bmax)的变化 ,探讨功能矫形的神经肌肉调控机理。方法　选用 2 0只 5周龄 Sprague- Dawley雄性大白鼠 ,随机分为实验组和对照组各 10只。实验组大鼠戴自制上颌功能矫治器 ,引导下颌前伸。采用放射受体分析法测定两组大鼠翼外肌肌细胞膜上乙酰胆碱受体的最大结合容量。结果　实验组大鼠翼外肌细胞膜上乙酰胆碱受体最大结合容量 ( Bmax=2 85 .5 73 fmol/mg pro)明显 >对照组 ( Bmax=2 14 .662 fmol/ mg Pro) ,其差异具有统计学意义 ( P<0 .0 1)。Objective The purpose of this study was to evaluate the maximum binding(Bmax)changes of acetylcholine receptor(n AchR)on rat lateral pterygoid muscle after the function mandibular advancemetn.Methods 20 five weeks old male Sprague Dawley rats were average divided to experiment and control groups.The mimic functional appliances were used in experiment groups and rats were killed after 2 weeks.Radio ligand binding assay(RBA) was applied to determine the maximun binding(Bmax)of n AchR on lateral pterygoid muscle.Results The Bmax of n AchR on experimental group is 285.573(fmol/mg Pro)and above the Bmax((214.662 fmol/mg Pro)of control( P <0.001).Conclusion The functional orthopedics can increase the Bmax of n AchR on rapid growing rat lateral pterygoid muscle.

关 键 词：功能矫形 翼外肌 乙酰胆碱受体 细胞膜 最大结合容量 影响研究 

分 类 号：R783.5[医药卫生—口腔医学]