心钠素对肝硬化患者血浆内皮素血管紧张素Ⅱ的影响  

Effect of exogenetic atrial natriuretic peptide on plasma endothelin and angiotensin Ⅱ in patients of cirrhosis ascites

作　　者：洪阳[1] 韦举卿[1] 周力[2] 芦源[2] 谭玉洁[2] 

机构地区：[1]贵阳市第一人民医院消化内科,550002 [2]贵阳医学院附属医院消化内科,550004

出　　处：《贵州医药》2002年第1期29-30,共2页Guizhou Medical Journal

摘　　要：目的应用外源性心钠素 (ANP) ,观察其对肝硬化患者血浆内皮素 (ET)、血管紧张素Ⅱ (ATII)等缩血管物质的影响。方法应用心血通注射液 (心钠素 )治疗 4 1例肝硬化患者 ,用放免法分别检测治疗前后血浆ANP、ET、ATⅡ的水平 ,同时检测 2 0例健康人。结果肝硬化组比正常组血浆ANP、ET、ATⅡ水平明显升高 (P <0 0 5 ) ;肝硬化患者血浆ANP与ET呈负相关 ,与ATⅡ无显著相关。外源性心钠素能降低childA级和 /或B级ET、ATII的水平 (P <0 0 5 ,P <0 0 1) ,对childC级无抑制作用。结论肝硬化患者血管扩张因子与血管收缩因子之间失衡 ,促进腹水及门脉高压的形成 ,外源性心钠素能部分调节它门之间的紊乱关系 ,对肝硬化失代偿期的治疗有重要价值。Objective To apply exogenetic atrial natriuretic peptide (ANP) to observe its effect on plasma endothelin (ET) and ang iotensin II (ATII) in patients of cirrhosis with ascites. Methods The plasma concentration of immunoreactive ANP, ET and ATII in samples were measured 41 patients with liver cirrhosis before and after treatment and 20 normal control. Results Cirrhotic cases showed that significantly higher ANP,ET and ATII than normal control( P <0.05). There were negative interrelated between ANP and ET, no interrelated between ANP and ATII. Conclusion The imbalance between blood vessel dilatation factor and systole factors are related to ascites formation and portal hypertension. To apply exogenetic ANP can partly correct their imbalance and have curative effect.

关 键 词：肝硬化 心钠素 内皮素 血管紧张素Ⅱ 影响 

分 类 号：R575.2[医药卫生—消化系统]