肝细胞癌p21蛋白与增殖细胞核抗原的表达  

p21 Protein and PCNA Expressions in Hepatocellular Carcinoma

作　　者：杨耘[1] 申丽娟[1] 张华献[1] 章宗籍[1] 

机构地区：[1]昆明医学院病理教研室,昆明650031

出　　处：《昆明医学院学报》2002年第1期11-13,共3页Journal of Kunming Medical College

基　　金：云南省自然科学基金 (2 0 0 0C0 0 5 8M);云南省教委科学研究基金 (0 0 110 10 )

摘　　要：应用免疫组化的方法对 5 9例肝细胞癌p2 1蛋白及增殖细胞核抗原的表达进行研究 ,并对两者在肝细胞癌中的表达关系进行比较 .结果显示 :p2 1在癌周肝组织的表达水平高于癌组织 ,在癌组织中的表达与肝细胞癌的分化程度有关 ,癌组织的分化降低 ,p2 1表达水平也随之降低 ;p2 1的表达与PCNA的表达呈负相关关系 (r =- 0 32 7,P <0 0 1) .提示 :p2 1的缺失表达可能促进PCNA合成的增加 。p21 protein and PCNA expressions in 59 cases of hepatocellullar carcinoma(HCC) were examined by immunohistochemical technique. The results showed that the expression of p21 protein in pericarcinoma tissues was significantly higher than those in HCC and it was closely correlated with histological differentiation grade. There was also a negative correlation between the expressions of p21 and PCNA in HCC tissues( r =-0 327, P<0 01).The results suggest that absent expression of p21 is correlative with progression of HCC.

关 键 词：肝细胞癌 P21蛋白 增殖细胞核抗原 免疫组织化学 PCNA 

分 类 号：R735.7[医药卫生—肿瘤]