消化性溃疡与局部体液免疫因子关系的研究  

A PRELIMINARY STUDY OF THE RELATION-SHIP BETWEEN PEPTIC ULCER AND LOCAL HUMORAL IMMUNE FACTORS

作　　者：闫明[1] 赵宪邨[1] 

机构地区：[1]山东医科大学附属医院,济南250012

出　　处：《胃肠病学和肝病学杂志》1993年第1期24-28,共5页Chinese Journal of Gastroenterology and Hepatology

摘　　要：本文对30例消化性溃疡手术标本进行了常规HE及体液免疫因子IgA、IgG、IgM、IgE、Lys、C_3的免疫组化染色。结果提示:溃疡病的发生及活动性与粘膜炎症有着密切关系,是重度炎症的结果;局部体液免疫反应可能是局部炎症和溃疡形成及演变的重要机制。因此,对于溃疡病的治疗和复发的预防应立足于胃、十二指肠炎症的防治以及对炎症中免疫反应的调控。Specimens of peptic ulcer of cases taken from surgical operation were sectioned and stained with routine HE and immunohistochemistry for IgA, IgG, IgM, IgE, Lys, C3 for demonstrating the relationship between the occurrence of ulcers and local humoral immunoreaction. The results suggest that peptic ulcer and its activity have a close relation to the inflammation of mucosa,and peptic ulcer may be a result of the severe inflammation. It shows that the local inflammation and activity of ulcers are all related to local humoral immune factors;that DU and GU may have distinct pathogenesis because they have a remarkable difference in their degree of correlation with local immune reaction. It may be one of the causes of the chronicity and unremarkable curative effect to peptic ulcer because local IgE increases reactively for a long-term and to be continued. We consider that the main efforts of treatment for peptic ulcer and prevention of recurrence should be focused on the management of mu-cosal inflammation and the regulation and control of local immune reaction.

关 键 词：消化性溃疡 体液免疫反应 发病机制 

分 类 号：R573.103[医药卫生—消化系统]