血浆、腹水中心钠素、加压素的测定及意义  

The Measurement of Atrial Natriuretic Peptide and Arginine Vasopressin in Plasma and Ascitic Fluid of Cirrhotic Patients with Ascites

作　　者：周新民[1] 许其增[2] 高河元[2] 刘英[2] 

机构地区：[1]第四军医大学西京医院,西安710032 [2]南京军区福州总医院

出　　处：《胃肠病学和肝病学杂志》1993年第2期41-43,共3页Chinese Journal of Gastroenterology and Hepatology

摘　　要：本文采用放射免疫分析法测定25例肝硬化腹水患者血浆、腹水中心钠素和加压素的水平,发现血浆、腹水中心钠素水平相当,均明显高于正常血浆水平;血浆加压素升高不明显,而腹水中加压素浓度显著高于血浆。结果提示心钠素和加压素的分泌释放异常,在肝硬化钠、水潴留及腹水形成中有一定的作用。腹水中高浓度的心钠素和加压素通过腹水回输可能起到一定的治疗作用。Atrial natriuretic peptide(ANP) and arginine vasopressin(AVP)in plasma and ascitic fluid were measured in 25 cirrhotic patients with ascites. Ascitic fluid ANP concentration was similar to plasma,both were significantly higher than that of normal plasma. Plasma AVP level was slightly higher but had no significant difference than normal plasma;while ascitic fluid AVP showed a markly increase than plasma. These data suggest that: (1)The abnormal secretion and releases of ANP and AVP may be contributed to sodium-water retention and ascites fromation in cirrhosis. (2)The high level ANP and AVP in ascitic fluid could have a treatment effect to patients with ascites receiving autotrartsfusion.

关 键 词：肝硬化 腹水 心钠素 加压素 

分 类 号：R575.202[医药卫生—消化系统]