全反式维甲酸治疗急性早幼粒细胞白血病13例报告  

All-trans Retinoic Acid in the Treatment of Acute Promyelocytic Leukemia—A Report of 13 Cases

作　　者：刘茂发[1] 丁凡[1] 肖承京[1] 孔庆芬[1] 鄢毅[1] 伍世礼[1] 张荣艳[1] 杨赣萍[1] 

机构地区：[1]江西医学院第一附属医院血液内科

出　　处：《江西医学院学报》1991年第1期47-49,共3页Acta Academiae Medicinae Jiangxi

摘　　要：报告国产全反式维甲酸诱导分化治疗13例急性早幼粒细胞白血病。均为初治患者,皆经未捎血象,骨髓象及组化确诊;男4例,女9例;年龄10～51岁,平均26岁。服药60～80mg/d,疗程36～55d,平均43d,总药量2 480～3 480mg,平均3000mg。13例中12例获完全缓解,1例死于DIC,完全缓解率达92％(12/13)。强调对并发症的治疗和缓解后继续巩固化疗。表明单用本药治疗优于一般联合化疗。All-trans retionic acid used in the treatment of thirteen patients with acute promyelocytic leukemia has been reported. All the patients were treated for the first time and had been diagnosed by examination of peripheral blood, bone marrow and histochemical means. Of the 13 patients, 4 were male and 9 female,aged from 10 to 51 years with an average of 26 years old. The dosage was 60～90 mg/d. The course of treatment was 36～55 days, averaged 43 days. The total dose was 2480～3480 mg,averaged 3000 mg. 12 of the 13 patients completely remitted, 1 died of DIC. The rate of complete remission was 92% (12/13). Emphasis was put on the treatment of complications and the maintenance of chemotherapy after remission. It is proved that using all--trans retinoic acid alone is better than combined chemotherapy.

关 键 词：白血病 维甲酸 急性 

分 类 号：R733.710.5[医药卫生—肿瘤] R730.53[医药卫生—临床医学]