口服维生素K_1对新生儿维生素K缺乏诱导蛋白的影响  

The effect of oral vitamin K_1 on protein induced by vitamin K absence Ⅱ in newborn infants

作　　者：梁友玲[1] 林超琼[1] 鲁杰[2] 

机构地区：[1]广西壮族自治区妇幼保健院,南宁530003 [2]首都儿科研究所

出　　处：《实用儿科临床杂志》2002年第1期5-6,共2页Journal of Applied Clinical Pediatrics

基　　金：卫生部科学研究基金课题 (项目编号 :96 - 2 .49)

摘　　要：目的　探讨口服维生素K1(VK1)对新生儿VK缺乏症诱导蛋白Ⅱ (PIVKA Ⅱ )的影响及口服VK1的最佳剂量。方法　随机将 10 1例足月新生儿分为口服VK12 .5mg组、5mg组及对照组三组 ,出生时均采集脐血 ,用酶联免疫吸附法测定PIVKA Ⅱ含量 ,3d后复查三组新生儿血PIVKA Ⅱ含量。结果　PIVKA Ⅱ≥ 2mg/ml人数 2 .5mg组由 8例降至 4例 ,5mg组由 11例降至 2例 ,对照组由 11例降至 8例。经统计学处理 ,2 .5mg组与 5mg组比较 P >0 .0 5 ;口服VK1组与对照组比较P <0 .0 5。结论　PIVKAObjective To study the changes of the concentration of PIVKA Ⅱ (protein induced by Vitamin K 1 absence Ⅱ) after different multiple oral doses of Vitamin K 1 (hereafter referred to as VK 1) given to normal newborn infants and to explore the optimal oral dose of VK 1 for prtecting newborn infants from VK 1 deficiency.Methods 101 cases of normal newborn infants were randomly divided into three groups. Group A took 2.5 mg VK 1 orally,group B took 5 mg VK 1 orally and the group C as the controls without VK 1 intake. Umbilical blood was collected at birth. The concentration of PIVKA Ⅱ was measured by enzyme linked immunosorbent assay (ELISA) and it was done again three days later. The normal concentration of PIVKA Ⅱ is below 2 mg/ml (PIVKA Ⅱ<2 mg/ml). If higher it means the deficiency of VK.Results The number of cases with PIVKA Ⅱ≥2 mg/ml reduced from 8 to 4 in group A with 2.5 mg;The number of cases with PIVKA Ⅱ≥2 mg/ml reduced from 11 to 2 in group B with 5 mg and the number of cases with PIVKA Ⅱ≥2 mg/ml reduced from 11 cases to 8 in the control group. There was no significant difference between group A and group B (P>0.05), but there was significant difference between the oral VK 1 group and the control group (P<0.05).Conclusion There are no changes or significant difference for PIVKA Ⅱ between group A and group B who were given oral intake of VK 1.

关 键 词：维生素K缺乏诱导蛋白 新生儿 维生素K 口服 凝血酶原 

分 类 号：R722.1[医药卫生—儿科]