活检胃粘膜核仁组成区嗜银蛋白观察研究  

Study of nucleolar organizer regions in biopsies of gastric mucosa

作　　者：王仰坤[1] 王恩升[1] 黄如川 

机构地区：[1]中国人民解放军第一五○医院

出　　处：《实用肿瘤杂志》1991年第3期150-152,共3页Journal of Practical Oncology

摘　　要：应用核仁组成区嗜银蛋白(AgNOR)技术对152例活检胃粘膜标本进行观察研究。结果良性病变AgNoR 计数在1.48至8.31个之间,银颗粒小,多数比较一致;恶性病变在4.62至19.75个之问,银颗粒大,不规则。从浅表性胃炎、萎缩性胃炎和异型增生到腺癌 AgNoR 数目渐增,颗粒体积渐大。尽管良性病变中的部分细胞银颗粒的最高值属于恶性病变中的计数范围之内,但每100个细胞中银颗粒≥4的细胞数在50%以下。提示AgNOR 技术对活检胃粘膜良、恶性病变的诊断和鉴别诊断及了解细胞增生变化的程度,判断细胞的生物学行为,上皮癌变过程与早期癌肿的发现均具有临床病理工作的实用性。This study has assessed the value of argyrophilic nucleolar organizer region(AgNOR)stai ning as a potential technique for resea rch in the gastric mucosa biopsied from 152 cases.Benign lesions ceils contained a mean number of 1.48～8.31 small uniform AgNORs per cell,whereas malignant lesions cells contained 4.62～19.75 frequently highly irreqular AgNORs.The correla- tion between benign and malignant lesions was highly significant(P<0.001).The authors found AgNOR to be of diagnostic value in differentiating the active degree of hyperlasia of the gastric mucosa,defining the frequency in the following check of the biopsies of the mucosa,and infer- ring the course of the canceration of the gastric mucosa.

关 键 词：核仁组成区 嗜银蛋白 胃粘膜 活检 

分 类 号：R730.43[医药卫生—肿瘤]