8Hz和16Hz单次次声作用后大鼠肺组织匀浆中细胞因子TNF-α及IL-8的变化  

Changes of TNF-α and IL-8 in the homogenate of lungs after the 8 Hz and 16 Hz infrasound operated on the rats

作　　者：李唯[1] 白汝芬 倪殿涛[1] 李焕章[1] 陈景藻 

机构地区：[1]第四军医大学西京医院呼吸内科,西安710032 [2]第四军医大学口腔医院药剂科 [3]西京医院呼吸理疗科

出　　处：《中国急救医学》2002年第3期127-129,共3页Chinese Journal of Critical Care Medicine

基　　金：全军重点基金课题 (No .96 2 0 42 )

摘　　要：目的　观察次声作用后肺组织匀浆中细胞因子TNF -α及IL - 8的变化。方法　SD大鼠 12 0只随机分为正常对照组、次声作用组 ,置本校研制的次声压力仓内致伤。次声作用组以 8Hz和 16Hz次声 ,声压分别为 90、10 0、110、12 0、130dB的强度 ,每次作用 2h。结果　 8Hz 90～ 130dB单次作用后TNF -α及IL - 8无明显变化。 16Hz 90dB次声单次作用即可引起肺组织匀浆中TNF -α及IL - 8的变化 ,与正常对照组相比有显著差异 (P <0 0 5 )。结论　在一定作用强度范围内 ,可较明显地反应其频率作用的特性。Objective Observation the changes of TNF-α and IL-8 in the homogenate of lung after infrasound operated.Methods 120 SD rats were randomized into normal groups and infrasound damage groups.8 Hz and 16 Hz 90?100?110?120?130 dB Results With 8 Hz 90～130 dB to the lungs once ,no influence in TNF-α and IL-8 were showed With 16 Hz 90 dB to the lungs once ,the changes of TNF-α and IL-8 compared with that of control group had more radical changes( P <0 05).Conclusions The changes of TNF-α and IL-8 in the homogenate of lungs is the similar to that of the damage to the lungs of rats.And the features of the frequency of infrasound was expressed within the scope of a certain intensity of infrasound over again.

关 键 词：次声 大鼠 细胞因子 肺组织匀浆 TNF-α IL-8 

分 类 号：R363[医药卫生—病理学]