缺血性脑卒中患者血浆溶血磷脂酸水平的初步研究  

Level of plasma lysophosphatidic acid in patients with cerebral ischemic attack, a preliminary study

作　　者：孙玉衡[1] 伍期专[2] 姚存姗[3] 黄世昌[2] 唐朝枢[4] 李振光[5] 包鹤丘[2] 李松[1] 周伟仅[4] 

机构地区：[1]首都医科大学附属北京积水潭医院神经内科,100035 [2]北京大学第一医院神经生化研究室 [3]解放军304医院神经内科 [4]北京大学第一医院心血管病研究所 [5]山东省威海市文登中心医院神经内科

出　　处：《中华医学杂志》2002年第4期229-231,共3页National Medical Journal of China

基　　金：国家 973重点基础研究发展规划资助项目(G2 0 0 0 0 5 690 5 0 )

摘　　要：目的　探讨短暂性脑供血不全发作 (TIA)和脑血栓形成以及疑似脑供血不全发作患者血浆溶血磷脂酸水平的变化。方法　采用有机溶剂抽提 ,并进一步分离出溶血磷脂酸 ,以定磷方法测定。结果　TIA和脑血栓形成以及疑似脑供血不全发作患者血浆溶血磷脂酸水平均显著高于对照组 (1 0 0 μmol/L± 0 70 μmol/L) ,分别为 2 14 μmol/L± 1 0 2 μmol/L、1 5 0 μmol/L± 0 85 μmol/L、1 73μmol/L± 1 14 μmol/L血浆 (P <0 0 5 )。经抗血小板聚集药物或抗凝血药物治疗患者血浆溶血磷脂酸水平下降。结论　作为体内凝血和血栓形成过程早期释放的分子标记物 。Objective To study the level of plasma lysophosphatidic acid (LPA) in patients with TIA, cerebral thrombosis or possible ischemic attack. Methods Phospholipid was extracted from plasma of patients with TIA, cerebral thrombosis or possible ischemic attack by organic solvent. Lysophosphatidic acid was isolated further. The quantity of LPA was determined by assaying its phosphorous component. Results LPA level of patients with TIA, cerebral thrombosis or possible ischemic attack were 2 14±1 02, 1 50±0 85, and 1 73±1 14 μmol/L blood plasma respectively, all significantly higher than that in control group (1 00±0 70 μmol/L, P <0 05). The plasma LPA level decreased after anticoagulant treatment. Conclusion As a molecular marker released by activated platelets in vivo, plasma PLA may be valuable in diagnosis of cerebral ischemic attack.

关 键 词：脑缺血 溶血磷脂酸类 诊断 TIA 脑血栓 卒中 

分 类 号：R743.3[医药卫生—神经病学与精神病学]