网脱术中阿霉素和地塞米松眼内注射的观察  

Intravitreal injection of doxorobicin and dexamethason in retinal detachment surgery.

作　　者：荣翱[1] 李锦文[1] 

机构地区：[1]同济大学附属同济医院眼科,200065

出　　处：《眼外伤职业眼病杂志》2002年第2期134-136,共3页Journal of Injuries and Occupational Diseases of the Eye with Ophthalmic Surgeries

摘　　要：目的　应用阿霉素及地塞米松在网脱术中注入玻璃体腔 ,观察对增生性视网膜玻璃体病变 (PVR)的抑制作用。方法　对 42例视网膜脱离伴PVR的患者施行手术加玻璃体腔药物注射 ,与单纯手术组 30眼视网膜脱离伴PVR作对比分析 ,并行有关血流动力学观察。结果　手术加注药物组与单纯手术组比较 ,术后 3～ 5月视网膜表面增生膜和网膜下机化膜比术前加重的发生率分别为 :7 14 %和 2 6 6 7% ,χ2 检验 :P <0 0 5。两组环扎术均可导致眼部血流动力学改变 ,术后 1～ 2周的视网膜中央动脉和中央静脉的收缩期最大平均流速分别为 ( 6 31± 2 5 )cm/s和 ( 4 77± 1 4)cm/s ,比正常值分别下降 33 6 6 %和16 6 6 %。Objective In a safety and an effective concentration,to investigate the inhibitory effect of doxorubicin and dexamethason intravitreal injection,in proliferative vitreoretinopathy.Methods 42 eyes of retinal detachment with proliferative vitreoretinopathy were underwent surgery with intravitreal injection of doxorobicin and dexamethason and 30 cases were underwent surgery only.All cases were followed up for 3～5 months.The hemodynamic changes of central retinal artery and vein were also evaluated.Results Most eyes were found to have retinal reattachment postoperativey.The changes of epiretinal membrane and subretinal membrane in two groups were different,7.14% patients in intravitrenl injection group and 26.6% patients in only surpery group were worse than preoperation,P<0.05.The encircling in two groups influenced the hemodynamic aspects of retinal central blood.Conclusion Combination of the two drugs in intravitreal use was thought to be of significant value on treatment of PVR.

关 键 词：阿霉素 地塞米松 玻璃体内注射 增生性视网膜玻璃体病变 网脱术 

分 类 号：R779.6[医药卫生—眼科]