中药炮制去毒机理探讨  

Studies on the Mechanism of Processing Toxic Chinese Herbs

作　　者：赵冬霞[1] 杜赢琨[1] 

机构地区：[1]云南中医学院，云南昆明650200

出　　处：《云南中医学院学报》2002年第1期22-26,30,共6页Journal of Yunnan University of Traditional Chinese Medicine

摘　　要：从有毒中药的炮制与其毒性改变的关系上 ,提出了炮制能改变药物毒性的因素 ,归纳为以下 7个方面 :(1)去除含毒性成分的部位 ;(2 )改变毒性成分的结构 ,使之转变成毒性较小而生理活性不减的物质 ;(3)降低毒性成分的含量 ;(4)除去非有效的水溶性毒性成分 ;(5 )破坏部分酶 ,以防有效成分发生化学变化生成毒性物质 ;(6 )破坏毒性成分结构 ,使之失去活性。 (7)辅料的解毒作用。This paper presented 7 factors concerning the relationship between processing toxic Chinese herbs and the toxicity,ablating poisonous part;changing the structure of the toxic compositon into substance with less poison and the same efficiency;reducing the content of toxic composition;ridding the inert toxic component solvable in water;destroying some enzyme to stop the formation of poison through active constituents;destroying the venenum structure into inefficient abstance;processing by the Chinese medicine with detoxication function.

关 键 词：有毒中药 炮制 去毒机理 毒性成分 

分 类 号：R283.1[医药卫生—中药学]