血浆多种神经肽与缺血性脑血管病相关性研究  

Relation between several plasma neuropeptides and cerebral ischemia disease

作　　者：林琳[1] 周维智[1] 朱咏新[1] 刘晓红[1] 

机构地区：[1]上海市普陀区人民医院神经内科,200060

出　　处：《脑与神经疾病杂志》2002年第1期1-4,共4页Journal of Brain and Nervous Diseases

摘　　要：目的 :探讨血浆多种神经肽在缺血性脑血管病中的作用。方法 :采用放射免疫法检测 112例不同类型缺血性脑血管病患者血浆降钙素基因相关肽 (CGRP)、内皮素 (ET)、心房利钠肽 (ANP)、神经肽 Y(NPY)、神经降压肽(NT)水平。结果 :急性脑梗死 CGRP、 NT较对照组降低 (P<0 .0 5 ) ,ET、 ANP、 NPY均较对照组升高 (P<0 .0 1) ,病情重者较轻者变化更显著 (P<0 .0 1) ,椎动脉供血不足组 CGRP、 ET、 ANP、 NPY均较对照组升高 (P<0 .0 1) ,脑动脉硬化组 ET较对照组升高 ,NT较对照组降低 (P<0 .0 5 ) ,其他神经肽变化不显著。结论 :神经肽参与了缺血性脑血管病病理生理过程 。Qbjective: To investigate etiological roles of several plasma neuropeptides in cerebral ischemia disease. Methods: The levels of calcitonin gene related peptide(CGRP), endothelin(ET), atrial natriuretic peptide(ANP), neuropeptide Y(NPY)and neurotensin(NT)in plasma were assayed by redioimmunoassay in 112 patients with different cerebral ischemia diseases. Results: In acute cerebral infarction group the plasma level of CGRP and NT were lower than those in control group (P<0.05), but plasma ET, ANP and NPY were higher than those in control group (p<0.01). These changes were more significant among intensive patients. The plasma CGRP, ET, ANP and NPY of patients with vertebro basic arterial insufficient were significantly higher than those in control group (P<0.01), but plasma ET, ANP and NPY were higher than those in control group (P<0.01). In cerebral arteriosclerosis patients the plasma ET was higher than that in control group and plasma NT was lower (P<0.05), other plasma neruopeptides have no change. Conclusion: These neuropeptides play a major role in pathophysological and pathogenetic mechanisms of cerebral ischemia disease. The changes can be regarded as one factor to decide prognosis of patients in early stage.

关 键 词：缺血性脑血管病 降钙素基因相关肽 内皮素 心房利钠肽 神经肽Y 神经降压肽 

分 类 号：R743.3[医药卫生—神经病学与精神病学] Q516[医药卫生—临床医学]