急性脑梗死溶栓治疗中血浆PAI-1及α2-AP的观察  

The Changes of PA1-1、α_2-AP in Thrombolytic Therapy of Acute Cerebral Infarction

作　　者：左宪华[1] 谢丽明[1] 李蕴琛[1] 姜昭[1] 

机构地区：[1]天津市第一中心医院神经内科,300192

出　　处：《脑与神经疾病杂志》2002年第1期13-15,共3页Journal of Brain and Nervous Diseases

基　　金：天津市科委自然基金科研项目

摘　　要：目的 :观察急性脑梗死 (ACI)溶栓治疗中血浆 PAI- 1(纤溶酶原激活物抑制物 )及 α2 - AP) (α2、抗纤溶酶 )的动态变化 ,探讨其临床意义。方法 :对 2 1例溶栓治疗组患者血浆 PAI- 1及 α2 - AP的活性进行动态监测 (OH,12 H,2 4 H,4 8H)并与 12例常规治疗组患者进行了比较。结果 :急性脑梗死患者 PAI- 1活性升高 ,溶栓后 12 H明显降低 ,2 4 H降至正常 ,4 8H仍处于正常水平。结论 :对急性脑梗死应用 5 0万 U尿激酶静脉点滴 ,12 H血浆 PAI- 1活性明显降低 ,2 4 H同剂量尿激酶再次应用 ,PAI- 1活性 80 %仍在降低 ,4 8H达正常水平。临床观察 ,2 1例病人无 1例并发出血。血浆 PAI- 1及 α2 -Objective:To observe the changes of PAI-1 and other markers in thrombolytic therapy of acute cerebral infarction (ACI), and approach their clinical significance. Methods: The PAI-1 and α2 AP activities were dynamically (hour 0,12,24,48 after thrombolytic therapy) determined in 21 patients with thrombolytic therapy, and 12 patients with routing therapy controls. Results: The PAI-1 activity of ACI increased, decreased significantly at 12 hrs after thrombolytic therapy, decreased and reached the normal level at 24 hrs after thrombolytic therapy, still in normal level at 48 hrs after thrombolytic therapy. Conclusion: ACI were treated with a dose of 500000 U urokinase as intravenous drip thrombolytic therapy, The PAI-1 activity decreased significantly at 12 hrs after thrombolytic therapy, the same dose urokinase was used at 24 hrs, The PAI-1 activities 80% decreased and reached the normal level at 48hrs. None of the 21 patients with thrombolytic therapy have hemorrhage complication. Monitoring the changes of PAI-1 activity will be able to instructe the thrombolytic therapy.\;

关 键 词：脑梗死 溶栓治疗 PAI-1 α2-AP 急性脑梗死 

分 类 号：R743.330.5[医药卫生—神经病学与精神病学]