低剂量格拉诺赛特(rhG-CSF)防治卵巢癌化疗后白细胞减少症的疗效观察  

Clinical Evaluation of Low Dose Granocyte (rhG-CSF) in Prevention and Treatment of Postchemotherapeutic Leukopenia of Ovarian Cancer

作　　者：张巧[1] 申桂华[1] 李寒松[1] 

机构地区：[1]卫生部北京医院妇产科,北京市100730

出　　处：《中国肿瘤临床》2002年第1期42-45,共4页Chinese Journal of Clinical Oncology

摘　　要：目的:探讨低剂量格拉诺赛特(rhG-CSF)的不同用法对卵巢癌化疗后白细胞和中性粒细胞减少的防治作用。方法:43例的上皮性卵巢癌化疗患者随机分为3组,其中,A组(共66疗程)不用rhG-CSF;B组(共57疗程)为白细胞计数<2.0×109/L时给予rhG-CSF,C组(共73疗程)自化疗结束后48小时起给予rhG-CSF,剂量均为50μg/日,皮下注射。结果:C组白细胞最低值的持续时间明显短于A和B组,分别为白细胞计数10日;中性粒细胞计数11日(P<0.01),平均最低值分别为3.01×109/L和0.986×109/L。B和C组rhG-CSF的作用并不随年龄、体重和化疗次数而改变。结论:rhG-CSF可以维持白细胞和中性粒细胞的水平,早期应用G-CSF可能会增大化疗剂量或缩短化疗间歇时间,从而提高化疗强度。Objective:To study the efficacy and safety of low dose Granocyte on leukope-nia and neutropenia induced by chemotherapy in ovarian cancer patients.Methods:Forty-three postoperative ovarian cancer patients treated with chemotherapy were randomized into three groups.In group A(66therapeutic courses)G-CSF was not given,in group B(57courses)50ug /day of G-CSF was given with WBC count less than2.0×10 9 /L,while in group C(73courses)Gra nocyte50ug /day hypodermically was given48hour after chemotherapy.Results:The time to nadir was significantly shorter in group C compared with group A and B and revealed10days for WBC count and11days for neutrophil count (P<0.01)with the mean nadir values of3.01×10 9 /L and0.986×10 9 /L respectively,and so the count of WBC and neutrophil have been kept during the course.The effect of G-CSF was not modified by age,body weight or the number of chemother-apy courses in group B and C Conclusion:These results demonstrate that early treatment with G-CSF may allow increased intensity of chemotherapy by using greater doses or by shortening the interval between cycles.

关 键 词：卵巢癌 格拉诺赛特 化疗 白细胞减少症 疗效 

分 类 号：R737.31[医药卫生—肿瘤] R730.53[医药卫生—临床医学]