雌孕激素受体及表皮生长因子受体在肝海绵状血管瘤中的表达及其意义  

The expression and significance of estrogen, progesterone and epidermic growth factor receptor in cavernous hemangioma of liver

作　　者：王志亮[1] 李国威[1] 程颖波[1] 

机构地区：[1]西安交通大学第二医院普外科,西安710004

出　　处：《西安医科大学学报》2002年第1期44-46,共3页Journal of Xi'an Medical University(Chinese)

基　　金：陕西省科技攻关基金资助项目 ( 98K12 G32 )

摘　　要：目的　探讨肝海绵状血管瘤 (CHL)与性激素及其受体的关系。方法　采用同位素放免法测定 3 8例CHL患者术前外周血性激素 (E2 、PRO、T)水平 ,免疫组化ABC法检测瘤组织中激素受体 (ER、PR、EGFR)的表达。结果　①CHL男性患者外周血清雌二醇 (E2 )水平明显高于正常男性 ,而女性CHL患者血睾酮 (T)及雌二醇 (E2 )的水平却较正常女性为低 ;②增殖型和萎缩型CHL患者外周血E2 、PRO、T无差别 ;③ER在增殖型CHL组织中的表达明显高于萎缩型 ,差别显著 ,EGFR在增殖型和萎缩型中均有高表达 ,但两型比较无差别 ,PR在两型中的表达很低。结论　CHL男性患者血雌二醇增高 ,而女性血睾酮及雌二醇降低。CHL为雌激素依赖性肿瘤 。Objective To discuss the relations of sex hormone receptor and hepatic cavernous hemangionmas.Methods Blood sex hormone (estradiol, progesterone, testosterone) and tumor tissue hormone receptor (estrogen receptor, progesterone receptor, epidermic growth factor receptor) had been analysed by reviewing method. Results ①Blood estradiol level was higher than that of male normal cases. But blood testosterone level and Estradiol level was lower than that of female normal cases; ②Blood estradiol, progesterone, testosterone levels of proliferative type of CHL cases were not different from atrophic type: ③Estrogen receptors of proliferative type CHL tissue were higher than that of atrophic type, and there were obvious difference. Epidermic growth factor receptors of proliferative type and atrophic type CHL tissue were all very high, but compared with each other, there was no difference. Progesterone receptors of these two types were very low, and there was no difference.Conclusion Blood estradiol concentration of CHL cases increases, but women blood testosterone and estradiol decreases, CHL is estrogen dependent tumor. High expression of estrogen receptor and epidermic growth factor receptor of tumor tissue may be related to the proliferation of CHL.

关 键 词：肝脏 海绵状血管瘤 性激素受体 CHL ER PR EGFR 肝肿瘤 

分 类 号：R735.7[医药卫生—肿瘤]