准分子激光原位角膜磨镶术后泪膜的早期改变  

The early changes of tear film after laser in situ keratomileusis

作　　者：杨斌[1] 王铮[1] 吴君舒[1] 黄国富[1] 许宗利[2] 

机构地区：[1]中山大学中山眼科中心,广州510060 [2]中山大学统计学教研室,广州510060

出　　处：《中华眼科杂志》2002年第2期76-80,共5页Chinese Journal of Ophthalmology

摘　　要：目的　探讨准分子激光原位角膜磨镶术 (laserinsitukeratomileusis ,LASIK)术后泪膜的早期改变。方法　对 74例 (14 8只眼 )近视患者行LASIK ,观察术前 ,术后 1d、1周、1个月、3个月的干眼症状 ,包括干涩感、异物感、烧灼感 ,以及荧光素试验、孟加拉玫瑰红染色、泪膜破裂时间 (breakuptimeoftearfilm ,BUT)和泪液分泌量结果 ,并对数据进行统计学分析。结果　术后 1周干燥感较术前加重(P <0 0 12 7) ,其他时间与术前比较差异均无显著意义 (P >0 0 12 7) ;术后 1d和 1周烧灼感较术前加重 (P <0 0 12 7) ,术后 1个月、3个月与术前比较差异无显著意义 (P >0 0 12 7) ;术后 1d、1周和1个月异物感较术前明显加重 (P <0 0 12 7) ,3个月接近术前水平 (P >0 0 12 7)。术后 1d和 1周角膜荧光素着色点较术前明显增多 (P <0 0 12 7) ,术后 1个月和 3个月与术前比较差异无显著意义(P >0 0 12 7) ;术后 1d和 1周孟加拉玫瑰红着色点较术前明显增多 ,差异有显著意义 (P <0 0 12 7) ,术后 1个月和 3个月接近术前水平 (P >0 0 12 7) ;术后 1周和 3个月泪液分泌量较术前明显减少 ,差异有显著意义 (P <0 0 5 ) ,术后 1个月接近术前水平 (P >0 0 5 ) ;术后 1d、1周、1个月和 3个月BUT均较术前缩短 (P <0 0 5 )。Objective To investigate the early changes of tear film after laser in situ keratomileusis (LASIK). Methods One hundred and forty eight myopic eyes that underwent LASIK were randomly chosen. The eyes were observed for subjective complaints of dry eye, fluorescein staining (Fl), rose bengal staining (Rb), tear break up time (BUT), Schirmer′s Ⅰ test preoperatively and 1 day, 1 week, 1 month, 3 months postoperatively. Results The subjective complaints of dry eye were more severe after the operation. There were obvious decreases in BUT at 1 day, 1 week, 1 month and 3 months postoperatively relative to the preoperative level ( P <0 05). The Schirmer′s Ⅰ test result was higher at 1 day but without statistical significance ( P >0 05), but lower at 1 week, 3 months ( P <0 05) after LASIK. No changes were observed in Schirmer′s Ⅰ test between preoperative and 1 month postoperative value ( P >0 05). Rb and Fl staining dots were more concentrated at 1 day and 1 week postoperatively ( P <0 012 7). No significant changes were found in Rb staining at 1 month and 3 months postoperatively. Conclusion LASIK does have some effects on tear film.

关 键 词：准分子激光原位角膜磨镶术 泪膜 泪膜破裂时间 眼外科手术 

分 类 号：R779.63[医药卫生—眼科]