小剂量环孢素合并糖皮质激素治疗多发性硬化  

Combination of Small Dose Cyclosporine and Prednisone for the Treatment of Multiple Sclerosis

作　　者：杨炼红[1] 邢诒刚[1] 陶恩祥[1] 

机构地区：[1]中山医科大学孙逸仙纪念医院神经科,广东广州510120

出　　处：《中山医科大学学报》2002年第2期137-139,142,共4页Academic Journal of Sun Yat-sen University of Medical Sciences

摘　　要：【目的】探讨环孢素 (Cs)治疗多发性硬化的疗效。【方法】将 5 9例多发性硬化患者随机分成两组 :30例采用小剂量Cs(5mg·kg-1·d-1)合并激素治疗 (治疗组 ) ,2 9例单用激素治疗 (对照组 ) ,疗程 1年。治疗后每月统计扩充致残量表(EDSS)评分 ,治疗前后统计脑脊髓MRI的总病灶数、检查脑干诱发电位 (BAEP)和视觉诱发电位 (VEP)。【结果】治疗组EDSS评分逐渐下降 ,治疗后 3个月开始显效 ,1年后效果更好 ,脑MRI病灶数减少 (P <0 0 1) ,BAEP和VEP的异常明显改善 ,疗效优于对照组 (P <0 0 5 )。治疗组病情轻～中度者疗效好。【结论】Cs治疗多发性硬化效果良好 ,副作用少。疗效与治疗时间长短、病情轻重有关。Objective To determine the efficacy of cyclosporine (Cs) for the treatment of multiple sclerosis (MS). Methods Fifty-nine MS patients were divided into two groups: thirty patients took Cs with initial dosage of 5 mg·kg -1 ·d -1 together with prednisone for one year while other twenty-nine patients took prednisone only. The Kurtzke Expanded Disability Status Scale (EDSS) score of each patient was compared monthly, and the number of the lesions on the brain and spinal MRI of each patient was compared before and after treatment. Further more, the brainstem auditory evoked potential (BAEP) and visual evoked potential (VEP) of each patient were compared before and after treatment. Results There was a significant decrease in the EDSS or in the number of MRI lesions and progresses of BAEP and VEP with Cs treatment (P<0.01), and further decrease in EDSS was found after 1 year. Conclusion Cs has satisfactory efficacy with no serious side effects for the treatment of MS. The efficacy is effected by patient's situations and the period of treatment.

关 键 词：多发性硬化 环孢素 扩充致残量表 糖皮质激素 治疗 

分 类 号：R744.51[医药卫生—神经病学与精神病学]