术前介入治疗对非小细胞性肺癌细胞凋亡的影响  

Study on Apoptosis in Non - small - cell Lung Cancer with Pre - operative Interventional Treatment

作　　者：孙 钢[1] 谢宗贵[1] 耿 明[1] 董 冰[2] 

机构地区：[1]济南军区总医院,250031 [2]济南市第四人民医院

出　　处：《中国医学计算机成像杂志》2002年第1期20-22,共3页Chinese Computed Medical Imaging

摘　　要：目的:研究介入治疗对非小细胞肺癌细胞凋亡的影响,探讨介入治疗术前应用的疗效。材料和方法:采用流式细胞仪与免疫组化方法检测介入治疗后行手术35例标本和单纯手术31例标本的细胞凋亡率、p53和bcl-2蛋白表达。结果:介入治疗组的细胞凋亡率明显高于单纯手术组（p<0.05）;介入治疗组的 p53蛋白阳性表达明显低于单纯手术组（p<0.05）;介入治疗组的bcl-2蛋白阳性表达与单纯手术组相比略有升高,但无显著性差异（p>0.05）。结论:介入治疗可促进细胞凋亡,近期疗效较好,同时术前介入治疗可诱导肿瘤细胞的多药耐药性产生,疗程不宜过长。Purpose: To study the apoptosis in non - small - cell lung cancer(NSCLC) with preoperative interventional treatment and the effect of preoperative transcatheter arterial chemotherapy on NSCLC. Materials and Methods:66 cases of histologically verified NSCLC specimens were studied. 31 patients were treated with surgical resection only. 35 cases were treated by second stage surgical resection after interventional treatment. Flow cytometry was used to observe the apoptosis,immunohistochemistry was used to examine p53 and bcl - 2. Results: The rate of apoptosis in the interventional treatment group was obviously higher than that in the sole surgical resection group(p <0.01); the expression of p53 in the interventional treatment group was signifieantes lower than that in the sole surgical resection group(p < 0.05); the expression of bcl - 2 in the interventional treatment group was slightly higher that in the sole surgical resection group, but there was no significant differenceCp > 0.05) .Conclusion: Apoptosis was induced in NSCLC after interventional treatment. It is appropriate to give a brief course of interventional treatment for fear of induction of drug resistance by transeatheter arterial chemotherapy.

关 键 词：肺癌 介入性放射学 细胞凋亡 蛋白质P53 蛋白质BCL-2 治疗 

分 类 号：R734.2[医药卫生—肿瘤]