西酞普兰治疗抑郁障碍的临床研究  

Clinical trial of citalopram in the treatment of depressive disorders

作　　者：王传跃[1] 唐永怡[1] 周沫[2] 成秀芳[3] 

机构地区：[1]首都医科大学附属北京安定医院,北京100088 [2]北京大学精神卫生研究所,北京100083 [3]北京回龙观医院,北京100096

出　　处：《中国新药杂志》2002年第2期156-158,共3页Chinese Journal of New Drugs

摘　　要：目的 :观察西酞普兰治疗抑郁障碍的疗效和安全性。方法 :采用多中心开放试验 ,纳入 2 9例单相抑郁或双相障碍抑郁发作患者。西酞普兰非固定剂量治疗 6周。汉密尔顿抑郁量表 (HAMD)评定疗效 ,治疗时出现的症状量表 (TESS)评定安全性。结果 :西酞普兰平均剂量 (2 9.3± 12 .2 )mg·d-1,有效率为 72 .4 % (2 1/ 2 9) ,临床痊愈率为 5 1.7% (15 / 2 9) ,起效时间大约在 3～ 4周。不良反应少见且程度轻 ,常见不良反应为口干 (13.8% )、头昏(10 .3% )和便秘 (10 .3% )。结论 :西酞普兰治疗抑郁症安全有效。Objective:To assess the efficacy and safety of citalopram in the treatment of depressive disorders.Methods:29 patients with depression were enrolled into the multicentre open trial. The patients received the flexible dose of citalopram in the course of 6 weeks treatment. The efficacy was assessed with Hamilton Depression Scale and the safety was assessed with Treatment Emergent Symptom Scale.Results:The average dose of citalopram was (29.3±12.2) mg·d -1 .The response rate was 72.4% (21/29) and the remission rate was 51.7% (15/29). The response time was around 3～4 weeks. There were less adverse reactions in the treatment of depressive disordors.Dry mouth (13.8%), dizziness (10.3%) and constipation (10.3%) were the frequent adverse reactions.Conclusion:Citalopram is an effective and safe antidepressant in the treatment of depressive disordors.

关 键 词：抑郁障碍 西酞普兰 安全性 治疗 

分 类 号：R749.41[医药卫生—神经病学与精神病学] R971.43[医药卫生—临床医学]