轻至中度阿尔茨海默病患者认知和生活功能的自然演变  

The natural deterioration of cognitive function and activities of daily living in patients with mild-to-moderate degree of Alzheimer's disease.

作　　者：盛建华[1] 高之旭[1] 翁正[1] 柴新生[2] 

机构地区：[1]上海市精神卫生中心,上海200030 [2]山东省精神卫生中心

出　　处：《中国神经精神疾病杂志》2002年第1期30-32,共3页Chinese Journal of Nervous and Mental Diseases

摘　　要：目的　了解阿尔茨海默病 (AD)认知和生活功能的自然演变。方法　对不服任何益智药的 30例轻度和 2 1例中度AD病人连续随访 30周。以简易智能状态检查量表 (MMSE)、Alzheimers痴呆缺陷量表 (ADS)、日常生活能力量表 (ADL)、成人韦氏记忆量表 (WMS)为评定工具 ,每 6周评定 1次。结果　 30周后 ,MMSE平均下降 (0 .2 5± 2 .5 8)分 (P >0 .0 5 ) ,ADS平均下降 (1.6 3± 4 .33)分 (P <0 .0 5 ) ,ADL平均上升 (2 .0 4± 6 .76 )分 (P <0 .0 5 ) ,WMS平均上升(3.37± 9.2 4 )分 (P <0 .0 5 )。结论　轻至中度AD病人认知功能和日常生活能力是缓慢减退的。轻至中度AD病人仍有低水平的学习能力。Objective To understand the natural deterioration of cognitive function and activities of daily living in patients with Alzheimers disease (AD). Methods We had followed up 30 patients with mild degree of AD and 21 patients with moderate degree of AD who didnt take any nootropics for 30 weeks. All subjects were measured by MMSE, ADS, ADL and WMS every six weeks. Results After 30 weeks, the mean score of MMSE decreased by 0.25±2.58 ( P >0.05), the mean score of ADS decreased by 1.63±4.33( P < 0.05 ), the mean score of ADL increased by 2.04±6.76( P <0.05), the mean score of WMS increased by 3.37±9.24( P < 0.05 ). Conclusions Natural deterioration of cognitive function and activities of daily living in patients with mild to moderate degree of AD is slow. The patients with mild to moderate degree of AD may maintain some learning ability.

关 键 词：阿尔茨海默病 认知功能 日常生活能力 自然演变 

分 类 号：R749.16[医药卫生—神经病学与精神病学]