甲状旁腺腺瘤和增生的^(99)Tc^m-MIBI甲状旁腺显像特点及其临床价值  

Characteristic and clinical value of double phase ^(99)Tc^m-MIBI parathyroid imaging for parathyroid adenomas and hyperplasia

作　　者：侯英萍[1] 邓敬兰[1] 乔宏庆[1] 汪静[1] 林国城[1] 

机构地区：[1]第四军医大学西京医院核医学科,陕西西安710032

出　　处：《中国临床医学影像杂志》2002年第1期6-9,共4页Journal of China Clinic Medical Imaging

摘　　要：目的:探讨甲状旁腺腺瘤和甲状旁腺增生的99Tcm-MIBI双时相甲状旁腺显像特点及其临床价值。方法:对12例正常对照者和22例经手术病理证实为甲状旁腺腺瘤(19例)和甲状旁腺增生(3例)的原发性甲状旁腺功能亢进患者进行99Tcm-MIBI双时相甲状旁腺显像,计算并比较摄取比值。结果:99Tcm-MIBI双时相显像定性检测腺瘤病灶的灵敏度初始相和延迟相分别为84.2%(16?19)和100%(19?19),定性检测增生病灶的灵敏度仅为33.3%(1?3)。腺瘤病灶部位99Tcm-MIBI高度浓聚呈异常聚集影灶,初始相和延迟相摄取比值均高于正常对照者(P<0.01～0.05)。增生病灶部位99Tcm-MIBI轻～中度浓聚呈弥漫性影像。结论:99Tcm-MIBI双时相法检测腺瘤病灶的灵敏度明显高于增生病灶,对异位甲状旁腺腺瘤的定位诊断很有帮助。Objective:To investigate the characteristic features and clinical value of double phase 99 Tc m -MIBI parathyroid imaging for parathyroid adenomas and parathyroid hyperplasia.Methods:Double phase 99 Tc m -MIBI parathyroid imaging was performed in12normal controls and22patients with primary hyperparathyroidism,in whom19cases with parathyroid adeno-mas and3cases with parathyroid hyperplasia were confirmed by surgery and pathology.The uptake ratio was calculated and compared.Results:The sensitivity of 99 Tc m -MIBI early and delayed phase imaging in detecting lesions of parathyroid adenomas was84.2%and100%respectively.The sensitivity in detecting lesions of hyperplasia was only33.3%.The adenomatous lesions clearly showed high radioactivity accumulation and presented focal uptake of 99 Tc m -MIBI ,the uptake ratio of the early phase and delayed phase was higher than that of the normal controls(P<0.01～0.05).The hyperplastic lesions showed mild-medium in-crease in activity and presented diffuse uptake of 99 Tc m -MIBI .Conclusions:The sensitivity of double phase 99 Tc m -MIBI imaging in detecting the lesions of adenomas was significantly higher than that of hyperplasia.It is a promising technique for the local-ization of ectopic parathyroid adenomas.

关 键 词：甲状旁腺肿瘤 腺瘤 放射性核素显像 诊断 甲状旁腺增生 ^99Tc^m-MIBI双时相甲状旁腺显像 

分 类 号：R736.2[医药卫生—肿瘤] R582.1[医药卫生—临床医学]