碱性成纤维细胞生长因子和异体下颌骨复合移植的实验研究  

Experimental study on allogeneic mandible transplantation combined with basic fibroblast growth factor

作　　者：朱慧勇[1] 吴求亮[1] 章明[2] 胡济安[3] 曹之强[1] 李松英[3] 

机构地区：[1]浙江大学医学院附属第一医院,浙江杭州310003 [2]浙江大学医学院,浙江杭州310031 [3]浙江大学医学院附属口腔医院,浙江杭州310006

出　　处：《浙江大学学报（医学版）》2002年第1期26-29,共4页Journal of Zhejiang University(Medical Sciences)

基　　金：浙江省自然科学基金项目 (396 44 6 )

摘　　要：目的 :探讨碱性成纤维细胞生长因子 (b- FGF)对异体下颌骨移植后再血管化及骨改建的影响 ,评价b- FGF和异体骨复合移植修复下颌骨缺损的临床价值。方法 :在 2 0例双侧下颌骨缺损的兔模型中 ,左侧植入 b-FGF和异体骨修复作为实验组 ,右侧单纯异体骨修复作为对照组。植入后 1个月、3个月分别行墨汁明胶血管灌注透明法及组织学观察再血管化及骨改建的情况。结果 :b- FGF+异体骨组血管化较异体骨组完全 ,骨形成也较异体骨组早且充分。结论 :b- FGF可促进异体下颌骨移植后再血管化 ,在骨改建过程中有骨诱导作用 ,b-Objective: To study the effect of basic fibroblast growth factor (b FGF) on revascularization and bone remodeling of allogeneic mandible transplantation in repair of mandible defects in rabbits. Methods: The mandible defects of 20 adult rabbits were created in both sides. The defects on the left side were implanted with allogeneic bone and local administration of b FGF;the defects on the right side were only repaired with allogeneic bone as control group. At 1,3 months after operation,the revascularization and bone remodeling were observed by ink gelation vascular perfusion transparency and histological examination. Results: The allogeneic bone and b FGF group had more marked vascularization and more quick and complete bone formation than control group. Conclusion: b FGF can improve revascularization and bone formation after allogeneic mandible transplantation;allogeneic bone combined with b FGF is a promising bone substitute in clinical uses.

关 键 词：碱性成纤维细胞生长因子 药理学 下颌骨移植 兔 实验研究 同种异体移植 

分 类 号：R738.1[医药卫生—肿瘤]