口腔鳞癌血管密度与增殖细胞比率关系的研究  

Quantitative Study of Microvascular Density and Proliferating Cell Ratio in Oral Squamous Cell Carcinoma

作　　者：尹晓东[1] 李吉辰[1] 胡腾龙[1] 李晓刚[1] 高瑞驹[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院,黑龙江,哈尔滨,150001

出　　处：《黑龙江医学》2002年第2期85-86,共2页Heilongjiang Medical Journal

基　　金：研究生课题

摘　　要：目的　探讨口腔鳞癌血管密度与增殖细胞比率的相关性。方法　采用ABC酶标法对 8例健康人口腔粘膜、15例口腔癌前病变组织、4 3例口腔鳞癌标本 ,分别检测其F8-RA和PCNA的表达。结果　ABC法比HE染色法更直观、特异 ,并有更高的阳性率。血管密度和增殖细胞比率 3组比较逐渐递增 ,1组与 2组比较无显著性差异。 3组与前 2组比较差异有显著性。血管密度和增殖细胞比率在口腔鳞癌病理不同分级之间比较 ,有显著性差异。结论　口腔鳞癌血管密度和增殖细胞比率呈现直线正相关。这 2个指标互相促进 。Objective Todiscuss the relation between microvascular density and proliferating cell ratio in oral squamous cell carcinoma. Methods The ABC enzyme labeling method was used in this research to examine the expression of F8-RA and PCNA in healthy oral mucosa (n=8), oral precancerous (n=15)and oral squamous cell carcinoma (n=43). Results The ABC method was more clearly, more special and had higher positive rate than HE staining. Both VD and proliferating cell ratio were increased gradually among three groups. There was no difference between Group 1 and Group 2. There existed significant difference between Group 3 and other. VD proliferating cell ratio had marked difference among different OSCC pathological grades. Conclusion it showed a linear positive correlation statistically between VD and proliferating cell ratio of OSCC. These two norms promoted each other causing biological behavior of OSCC embodied fully.

关 键 词：口腔鳞癌 血管密度 免疫组化 癌前病变 细胞增殖 

分 类 号：R739.8[医药卫生—肿瘤]