帕米膦酸二钠治疗恶性肿瘤骨转移的观察  

Clinical study of pamidronate on cancer patients with bone metastasis

作　　者：赵增虎[1] 王利端[1] 丁瑞亮[1] 刘秀芳[1] 李成云[1] 

机构地区：[1]中国人民解放军第251医院,河北省张家口市075000

出　　处：《现代中西医结合杂志》2002年第5期377-379,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的 :观察帕米膦酸二钠 (搏宁 )对恶性肿瘤骨转移的临床疗效。方法 :3 8例恶性肿瘤患者静点搏宁 60～ 90 m g/次 ,部分病例联合静脉化疗 (n=16)。结果 :搏宁对骨痛治疗的有效率为78.95 % ,联合化疗的疗效 (有效率 87.5 % )优于单用搏宁 (有效率 72 .7% )。活动能力改善有效率为84.4% ,9例血钙增高患者经治疗后血钙复常率为 77.78%。不良反应主要为发热、食欲减退、恶心、全身酸痛等。结论 :搏宁能有效地缓解骨转移疼痛及改善活动功能障碍 ,提高患者的生活质量 。Objective: It is to observe the clinical efficacy of pamidronate (Bonin) on treatment of cancer patients with bone metastasis. Methods: Thirty-eight cancer patients with bone metastasis were administered 60~90mg dose of Bonin intravenously. Sixteen of them were combined with chemotherapy. Results: The total effective rate of Bonin on bone pain was 78.95%. The effective rate of combining with chemotherapy (87.5%) was higher than that of only receiving Bonin ( 72.7 %). The effective rate of moving ability improvement was 84.4%. After treatment, nine patients with hypercalcaemia whose serum calcium reduced to normal in 77.78%. Side effects were fever, anorexia, nausea and general malaise. Conclusion: Bonin is effective for relieving pain, improving immobility and the quality of life in advanced cancer patients. Its effects will be better if Bonin were combined with chemotherapy.

关 键 词：帕米膦酸二钠 骨痛 骨转移性 骨肿瘤 治疗 

分 类 号：R738.105[医药卫生—肿瘤]