低温海水浸泡大鼠的血气及肺脏前列腺素和降钙素基因相关肽变化的观察  

The changes in bloodgas analysis and pulmonary prostaglandin and calcitonin gene related peptide levels in rats after immersion in lowtemperature sea water

作　　者：姜忠华[1] 腾燕生 辛苏宁[1] 袁晓璐[1] 梁满军 张冬梅 杨东慧[1] 鲁青[1] 贾钢锐[1] 

机构地区：[1]解放军第四○一医院,山东青岛266071 [2]解放军青岛辛家庄干休所

出　　处：《中国危重病急救医学》2002年第3期141-143,共3页Chinese Critical Care Medicine

基　　金：海军医药卫生科研基金资助项目 ( No.0 0 HW0 9)

摘　　要：目的 :观察低温海水浸泡大鼠的血气及肺脏前列腺素 (PG)与降钙素基因相关肽 (CGRP)变化规律。方法 :将不同时间组大鼠分别置于 16 .5℃及 9.5℃低温海水中自由游动 ,沉入水面下以前迅速取出 ,于 15及30分钟分别测量大鼠肛温 ,抽左心血行血气分析 ,并取肺组织检测 PG及 CGRP含量。结果 :低温海水浸泡大鼠肛温、p H、6酮前列腺素 F1α(6 keto PGF1α)及 CGRP均明显降低 (P均 <0 .0 1) ,而血氧分压、二氧化碳分压、血栓素 B2 (TXB2 )则明显上升 (P<0 .0 5或 P<0 .0 1)。结论 :低温海水浸泡大鼠肺组织合成与分泌 PG及CGRP受低温、血气的影响 ,6 keto PGF1α与 CGRP降低以及 TXB2 上升则可能影响血气指标的改善。Objective:To observe changes in gasblood and pulmonary prostaglandin (PG) and calcitonin gene related peptide (CGRP) levels in rats after being immersed in lowtemperature brine.Methods:Different groups of rats were allowed to swim in brine of 16 5 ℃ and 9 5 ℃ respectively.The rectal temperature,bloodgas analysis for arterial blood from the left heart,and pulmonary tissue thromboxane B 2 (TXB 2),6ketoprostaglandin F 1α (6ketoPGF 1α ) as well as CGRP levels were determined in respective groups.Results:The rectal temperature,pH,6ketoPGF 1α and CGRP were obviously decreased (all P <0 01),while PO 2,PCO 2,and TXB 2 levels markedly increased ( P <0 05 or P <0 01).Conclusions:The results suggest that the production and release of PG and CGRP can be influenced by hypothermia and changes in bloodgas.Decrease in 6ketoPGF 1α as well as CGRP and increase in TXB 2 may influence the improvement of blood gases.

关 键 词：低温海水浸泡 血气分析 血栓素B2 6-酮-前列腺素F1Α 降钙素基因相关肽 

分 类 号：R363[医药卫生—病理学]