利用非线性优化方法进行脑磁源定位  

Nonlinear optimization methods for MEG source localization

作　　者：胡净[1] 胡洁[2] 

机构地区：[1]浙江工业大学信息工程学院,浙江杭州310032 [2]浙江大学附属第一医院设备科,浙江杭州310003

出　　处：《浙江工业大学学报》2002年第1期9-12,共4页Journal of Zhejiang University of Technology

基　　金：浙江工业大学校基金资助项目 (X3 0 3 5 )

摘　　要：脑磁图 (Magnetoencephalography ,MEG)用于人脑的诱发神经活动的成像 ,具有很好的时间分辨率 ,能无损地监测脑神经活动。本文探讨了脑磁的基本理论 ,中心问题是根据头外测得的磁场数据来进行脑磁源的定位 ,此逆问题属于不定问题 ,需加一些限制以期得到合理的解。本文的源模型和头模型采用均匀球头导体中的单电流偶极子模型 ,利用非线性优化方法反演脑磁源参数 ,并采用了一种综合的非线性优化法来提高反演的精度和速度。仿真实验表明该方法是可行有效的。Magnetoencephalography(MEG) is a noninvasive technique for investigating the neuronal activity in the living human brain, and it is of good time resolution. This paper discusses MEG's basic theory. The key question in the analysis is the search for the unknown sources by analysis of the measured magnetic field data outside the brain. As this inverse problem does not have the unique solution, so some restrictions are added to make the unique inverse solution possible. In this paper, the model uses a single current dipole in a spherical homogeneous medium. There are many nonlinear optimization methods to estimate the dipole parameters. Here in order to improve the iterative speed and accuracy, we present a synthesis method. Computer simulation demonstrates the effectiveness of the proposed method.

关 键 词：MEG 逆问题 单电流偶极子模型 均匀球头导体 非线性优化 脑磁图 脑磁源定位 头模型 源模型 

分 类 号：R338[医药卫生—人体生理学] R741.044[医药卫生—基础医学]