黏质沙雷氏菌苗治疗恶性胸腔积液的临床研究  

Serratia marcescens vaccine in the treatment of malignant pleural effusion

作　　者：史鹤玲[1] 朱允中[1] 徐丽艳[1] 刘喆[1] 游永红[1] 孟弃逸[1] 张新勇[1] 许军涛[1] 

机构地区：[1]北京胸部肿瘤结核病医院,101149

出　　处：《中华肿瘤杂志》2002年第2期188-190,共3页Chinese Journal of Oncology

摘　　要：目的　评价黏质沙雷氏菌苗 (S311)治疗恶性胸腔积液的疗效及毒副反应。方法　取S31110 9U(0 .32mg)于第 1,8,15天注入胸腔。观察 4周 ,评价疗效和毒副反应。结果　 34例患者中 ,完全缓解 (CR) 12例 ,部分缓解 (PR) 2 1例 ,总有效率 97.1% (33/ 34)。毒副反应较轻 ,有发热 (82 .4 % )、胸痛 (5 2 .9% )、恶心 (2 6 .5 % )、呼吸困难 (17.5 % )、寒战 (5 .9% )及呕吐 (2 .9% )。结论　S311治疗恶性胸腔积液疗效较好 ,毒副反应可以耐受 ,可以安全用于临床。Objective To evaluate the efficacy and toxicity of Serratia marce scens (S311) vaccine in the treatment of malignant pleural effusion. Methods Thirty four patients with malignant pleural effusion were given S311 as intrapleural injection with a dose of 10 9U (0.32mg) on D 1, 8 and 15, and o bserved for four weeKs. Results The overall response rate (CR+PR) was 97.1% (CR in 12 patien ts and PR in 21 patients). The sy stemic toxicity was mild, including fever (82.4 %), pleuritic pain (50.7%), nansea (26.5%), dy spnea (17.5%) and chills (5.9 %). Conclusion Serratia marcescens vaccine is effective for malignant pleural effusion, with tolerable toxic effects. Further study is warr anted. [

关 键 词：恶性胸腔积液 黏质沙雷氏菌苗 治疗 临床研究 疗效 

分 类 号：R730.5[医药卫生—肿瘤]