初治急性白血病患者肺耐药蛋白和多药耐药相关蛋白基因表达与预后的关系  

The relationship between expression of lung resistance-related protein gene or multidrug resistance-associated protein gene and prognosis in newly diagnosed acute leukemia

作　　者：赵瑜[1] 于力[1] 王全顺[1] 楼方定[1] 浦津[1] 

机构地区：[1]解放军总医院血液科,北京100853

出　　处：《中华内科杂志》2002年第3期183-185,共3页Chinese Journal of Internal Medicine

摘　　要：目的　探讨肺耐药蛋白 (lrp)基因和多药耐药相关蛋白 (mrp)基因表达与初治急性白血病 (AL)患者化疗效果的关系。方法　用逆转录聚合酶链反应方法检测 5 8例初治AL患者骨髓单个核细胞中lrp和mrp的mRNA表达。结果　初治急性淋巴细胞白血病 (ALL)患者lrp和mrp阳性表达率分别为 15 0 %和 4 0 0 % ,初治急性非淋巴细胞白血病 (ANLL)患者lrp和mrp阳性表达率分别为15 8%和 4 2 1% ;在ALL和ANLL组 ,lrp和mrp基因阳性与阴性患者的首次完全缓解 (CR)经统计学分析 ,差异无显著性 (P >0 0 5 ) ;而lrp和mrp基因双阳性与双阴性患者的首次CR经统计学分析 ,差异有显著性 (P <0 0 5 ) ;lrp和mrp基因两者无相关性。结论　lrp和mrp单独作为预测初治AL患者化疗效果的敏感性较差 。Objective To evaluate the relationship bewteen the expression of lung resistance related protein(lrp) gene or multidrug resistance associated protein (mrp) gene and prognosis in untreated acute leukemia (AL) patients Methods Reverse transcriptase polymerase chain reaction (RT PCR ) was used to examine the expression of lrp and mrp gene in 58 newly diagnosed AL patients Results The positive rate of lrp and mrp gene expression in newly diagnosed acute lymphocytic leukemia (ALL) group was 15 0% and 40 0% and it was 15 8% and 42 1% in newly diagnosed acute nonlymphocytic leukemia (ANLL) group In both the ALL and ANLL groups, the difference of the first complete remission rate in lrp negative and in lrp positive patients was not significant ( P >0 05), the same results were found with mrp gene The difference of the first complete remission rate between lrp + /mrp + and lrp -/mrp - patients was significant ( P <0 05) There was no relationship between lrp and mrp gene Conclusion Neither lrp nor mrp gene as a single indicator to forcast original multidrug resistance is sensitive, but lrp combined with mrp as one indicator will be sensitive

关 键 词：急性白血病 多药耐药性 聚合酶链反应 基因表达 预后 

分 类 号：R733.7[医药卫生—肿瘤]