肝癌栓塞内放射治疗后血酮体比检测的意义  

Arterial Ketone Body Ratio as Indicator in Liver Function

作　　者：李志辉[1] 严律南[1] 李立[1] 官泳松[2] 卢武胜[2] 李玉[1] 

机构地区：[1]四川大学华西医院普外科,成都610041 [2]四川大学华西医院介入科

出　　处：《中国普外基础与临床杂志》2002年第2期100-102,共3页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的　评估动脉血酮体比率 (arterialbloodketonebodyratio ,AKBR)与肝功能的关系及将其用于肝功能分级的可行性。方法　对我院 1994～ 1998年 44例不能切除的晚期肝癌患者施行3 2 P玻璃微球 (phosphorus 3 2 glassmicrospheres ,3 2 P GMS)肝动脉灌注治疗 ,手术前后以各项肝功能指标及AKBR等监测肝功能 ,并以AFP、CT、单光子衍射计算机断层成像 (singleprotonematiomcomputerizedtomography ,SPECT)等判断治疗效果 ;采用多因素相关分析 ,对AKBR与肝功能相关性进行分析 ,了解AKBR与肝功分级指标的关系。采用Spearmen等级相关了解AKBR值与肝功能及AKBR值与生存时间的关系。结果　AKBR值的大小与肝功能分级高低呈负相关 ,术前AKBR三个水平段与生存时间相关系数为 0 .44 0 9。Objective To estimate the relationship between arterial blood ketone body ratio (AKBR) and liver function and to appraise the feasibility of adding AKBR into liver function estimate. Methods From 1994 to 1998, 44 patients with unresectable liver cancer recieved the combined radio chemo embolization with mixed emulsion of phosphorus 32 glass microspheres ( 32 P GMS), chemo agent and glycerine or lipiodol, via intra operative hepatic artery instillation, hepatic artery ligation and operational arterial embolization (HAL+OAE) or transcatheter hepatic artery embolization (TAE). Preoperative and postoperative function and energy change level of the liver were tested by liver function test and AKBR. CT, SPECT, AFP were used to judge the therapy effect; multivariate statistical analysis methods were used to evaluate the correlation between AKBR and liver function. Spearmen rank correlation analysis was used to evaluate whether there was any relationship between AKBR and liver function test, and to evaluate that there was any relationship between AKBR and survival time. Results A negative correlation showed between the level of AKBR and liver function. The correlation coefficient of the three level of AKBR before operation and survival time was 0.4409. Conclusion AKBR can well reflect the degree of liver function.

关 键 词：动脉血酮体比率 肝癌 放射治疗 AKBR 肝功能分级 ^32P玻璃微球 

分 类 号：R735.7[医药卫生—肿瘤]