p27基因和转化生长因子βⅡ受体在胃癌组织中的表达  

Expression of p27 and TGF-βRⅡ in Human Gastric Carcinoma

作　　者：朱友群[1] 万美珍[1] 胡岳棣[1] 佘正尧[1] 史永娟[1] 

机构地区：[1]江苏省常州市肿瘤医院内科,213001

出　　处：《实用癌症杂志》2002年第2期139-141,共3页The Practical Journal of Cancer

摘　　要：目的　研究p2 7基因与转化生长因子 βⅡ型受体 (TGF βRⅡ )在胃癌组织中的表达及相互关系。 方法　采用免疫组化S P法 ,检测 62例胃癌组织中 p2 7蛋白、TGF βRⅡ的表达情况 ,结合病理及随访资料进行分析。 结果　胃癌中 p2 7、TGF βRⅡ表达的阳性率分别为 41.9% ( 2 6/ 62 )、17.7% ( 11/ 62 ) ,它们均与胃癌的Borrman分型、浸润深度相关 (P <0 .0 5 ) ,p2 7蛋白阳性表达还与淋巴结转移相关 (P <0 .0 5 ) ;随 p2 7蛋白表达强度增加 ,TGF βRⅡ阳性率增高 (P <0 .0 5 ) ;生存期超过 5年者其 p2 7蛋白、TGF βRⅡ的表达阳性率显著高于生存期 <5年者 (P <0 .0 5 )。 结论　p2 7蛋白和TGF βRⅡ与胃癌不良的生物学行为及预后相关 ,p2 7蛋白与TGF βRⅡ可作为判断胃癌预后的标志物。Objective To study the expression and significance of p27?TGF βRⅡ(Transforming growth factor βⅡ Receptor) in human gastric carcinoma(GC) and their relationship.Methods p27 and TGF βRⅡ in 62 GC tissues were detected by immunohistochemical S P technique.The clinicopathological and follow up data were analysed statistically.Results The positive rates of p27 and TGF βRⅡ were detected in 41.9%(26/62) and 17.7%(11/62) respectively.They were in relation to Borrman type,invasive depth( P <0.05).GC without lymph nodal metastasis showed higher positive p27 staining rates(66.7%) than those with nodal involvement(34.0%).TGF βRⅡ positive rates increased as p27 protein positive expression strength( P <0.05).Positive numbers of p27 protein and TGF βRⅡ were higher in over 5 year survival group than in under 5 years( P < 0.05 ).Conclusion Decrease of the expression of p27 and TGF βRⅡ are related with the poor biological behavior and prognosis.They may be used as prognosis markers in GC.

关 键 词：胃癌 P27基因 转化生长因子βⅡ受体 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]