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机构地区:[1]广东药学院药理教研室 [2]天津医药工业研究院
出 处:《中药药理与临床》1999年第2期19-21,共3页Pharmacology and Clinics of Chinese Materia Medica
摘 要:目的:研究茶多酚(TP)的抗过敏作用。方法:利用小鼠被动性皮肤过敏反应(PCA)实验、组织胺引起正常豚鼠离体回肠收缩试验、豚鼠SchultzDale回肠收缩反应以及测定过敏豚鼠肺脏SRSA含量等方法。结果:茶多酚能明显抑制小鼠被动性皮肤过敏反应、组胺所引起的回肠平滑肌收缩而使组胺收缩曲线右移,并抑制豚鼠SchultzDale反应的回肠收缩以及致敏豚鼠肺组织中SRSA的释放。AIM:Tea polyphenols (TP) are polyphenols extracted from the tea.In this report,the anti allergic effect of TP has been studied.METHODS:Passive cutaneous anaphylaxis(PCA) in mice and isolated guinea pig ileum test,Schultz Dale test in guinea pig’ileum and anti allergic medium(SRS A) secretion test were utilized respectively.RESULTS:The results indicated that TP inhibited significantly PCA of mice and the contractions of the guinea pig ileum induced by histamine and Schultz Dale reaction of guinea pig ileum in the dose dependent.TP at concentration of 10 7 ~10 5 g/ml inhibited SRS A secretion and evidently decreased the contractions of SRS A produced in the process of antigen restimulating.CONGLUSIONS:The anti allergic effect of TP is associated with inhibition of histamine and SRS A system.
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