常用中药肝毒性成分代谢与毒理研究进展  

Research progress on metabolism and toxicology of hepatotoxic components in common Chinese materia medica

作　　者：张凯 董晓敏 王琦 汪晓娟[1] ZHANG Kai;DONG Xiao-min;WANG Qi;WANG Xiao-juan(Department of Pharmacy,Fuyang People's Hospital,Fuyang 236000,China;Fuyang Attached Primary School,Fuyang 236000,China)

机构地区：[1]阜阳市人民医院药剂科,安徽阜阳236000 [2]阜阳市附小学校,安徽阜阳236000

出　　处：《中草药》2018年第22期5435-5447,共13页Chinese Traditional and Herbal Drugs

摘　　要：近年来,随着我国医药卫生健康产业的稳步发展,中医药逐步获得世界人民的认可和信赖,中药在临床治疗和养生保健方面的使用量逐步攀升,其研究价值也日益凸显。然而,中药在使用过程中伴随的毒副作用也引起广泛的关注,因中药制剂服用不当所导致肝功能损害时有报道。迫切需要深入研究和整理中药肝毒性机制,保障常用中药的临床安全有效。在查阅近几年来常见中药肝毒性相关文献的基础上,从代谢与分子方面深入分析常用中药肝毒性成分的毒理机制,以期为中药肝毒性研究提供新思路,为中药临床合理使用提供有益参考。In recent years, with the steady development of the medicine and health industry in China, Chinese medicine has gradually been recognised and trusted by people around the world, its application amount has being increased in clinic and health care. The worth of its research is also becoming more and more prominent. However, the toxicity and side effects of Chinese materia medica(CMM) have aroused widespread attention, the increasing number of patients with liver function damage has occurred. Thereby, it is urgent to further analyse and study the mechanism of liver toxicity of CMM to ensure the clinical safety and efficacy of common CMM. Based on the latest literatures about hepatotoxicity of common CMM in recent years, the present study analyzed the major mechanism of hepatotoxicity of CMM from the perspective of metabolism and toxicology, in order to provide a novel approach for hepatotoxicity investigation of CMM, and offer the useful reference for the rational application of CMM in clinic.

关 键 词：中药 肝毒性 毒性成分 代谢 毒理 

分 类 号：R285[医药卫生—中药学]