睡眠障碍对中老年鼻咽癌患者预后的影响  

Effects of sleep disorder on prognosis of middle-aged and elderly patients with nasopharyngeal carcinoma

作　　者：翁敬锦[1] 韦嘉章[1] 李敏[1] 陆锦龙[1] 覃扬达[1] 江河[1] 瞿申红[1] WENG Jing-fin;WEI Jia-zhang;LI Min;LU Jin-long;QIN Yang-da;JIANG He;QU Shen-hong(Department of Otolaryngology Head and Neck,the People's Hospital of Guangxi Zhuang Autonomous Region,Nanning530021,Guangxi,China)

机构地区：[1]广西壮族自治区人民医院耳鼻咽喉头颈科,广西南宁530021

出　　处：《广东医学》2018年第21期3192-3196,共5页Guangdong Medical Journal

基　　金：国家自然科学基金资助项目(编号:81460097);广西自然科学基金资助项目(编号:2017GXNSFAA198013);广西医药卫生科研课题(编号:Z2014629)

摘　　要：目的探讨睡眠障碍对中老年鼻咽癌(nasopharyngeal carcinoma,NPC)患者预后的影响。方法共纳入符合标准的315例NPC患者,其中睡眠障碍组42例,非睡眠障碍组273例。应用Kaplan-Meier生存曲线进行单因素生存分析,用log-rank检验进行组间生存曲线的比较,COX回归进行多因素分析。结果睡眠障碍组复发/转移率高于非睡眠障碍组(40. 48%vs 26. 01%,P <0. 05)。3年总生存率非睡眠障碍组为87. 75%,睡眠障碍组为77. 59%(P <0. 05)。多因素分析显示,T分期、N分期、治疗方式、放疗方式和睡眠情况是影响NPC患者总生存率的独立危险因素,T分期、N分期和治疗方式是影响NPC患者无瘤生存率的独立危险因素。结论睡眠障碍是影响NPC预后的独立危险因素,对睡眠障碍患者可能需要进一步干预。Objective To investigate the effects of sleep disorder on prognosis in middle-aged and elderly patients with nasopharyngeal carcinoma( NPC). Methods A total of 315 patients with NPC were enrolled in the study.The patients were divided into sleep disorder group( n = 42) and healthy sleep group( n = 273). Kaplan-Meier survival curves were applied for single factor survival analysis,and log-rank tests were used to compare the survival curves between groups. Results The recurrence/metastasis rate was significantly higher in the sleep disorder group than that in the healthy sleep group( 40. 48% vs. 26. 01%,P < 0. 05). The 3-year overall survival rate( OS) was 87. 75% in the healthy sleep group and 77. 59% in the sleep disorder group( P < 0. 05). Multivariate analysis showed that T stage,N stage,therapeutic schedule,radiotherapy modalities and sleep disorder were independent risk factors impact on OS of patients with NPC. T stage,N stage and radiotherapy modalities were independent risk factors influencing DFS in patients with NPC( All P < 0. 05). Conclusion Sleep disorder is an independent risk factor that affects the prognosis of middle-aged and elderly patients with NPC,and further intervention may be required for patients with sleep disorders.

关 键 词：鼻咽癌 睡眠障碍 预后 

分 类 号：R739.63[医药卫生—肿瘤]