以下颌骨骨髓炎为首发症状的SAPHO综合征5例临床分析  

Clinical analysis of 5 cases of SAPHO syndrome with mandible osteomyelitis as initial presentation

作　　者：高炳菊 李军 潘丽珍[1] 邱宇[1] 林李嵩[1] GAO Bing-ju;LI Jun;PAN IA-zhen;QIU Yu;LIN Li-song(Department of Oral and Maxillofacial Surgery,The First Affliated Hospital of Fujian Medical University,Laboratory of Facial Plastic and Reconstructive Surgery,Fujian Maxillofacial Medical Center.Fuzhou 350005,Fujian Province,China)

机构地区：[1]福建医科大学附属第一医院口腔颌面外科,福建医科大学面部整复与重建研究室,福建省颌面医学中心,福建福州350005

出　　处：《中国口腔颌面外科杂志》2018年第6期528-532,共5页China Journal of Oral and Maxillofacial Surgery

基　　金：福建省自然科学基金(2016J01452)

摘　　要：目的:探讨以下颌骨红肿、疼痛,伴或不伴开口受限为主要临床表现的SAPHO病例的诊断和治疗。方法:通过回顾我科诊治的5例SAPHO患者的临床资料,结合相关文献报道,分析并讨论SAPHO相关的下颌骨骨髓炎在临床表现、诊断及治疗方面的特点。结果:以下颌骨红肿、疼痛,开口受限为主要临床表现的SAPHO,与弥漫性硬化性下颌骨骨髓炎类似,极易混淆。治疗上应以保守治疗为主,不提倡手术治疗。结论:SAPHO是一种少见疾病,发生在下颌骨者更是罕见,应加强对此类疾病的认识,掌握其诊断标准,提高早期诊断率,减少不必要的有创操作及手术。PURPOSE:To discuss the diagnosis and treatment of SAPHO patients whose main symptoms were painful swelling and inflammation of the mandible,with or without restriction of mouth opening.METHODS:The clinical data of 5patients with SAPHO in our department were reviewed,clinical manifestations,diagnosis and treatment of SAPHO related osteomyelitis of the mandible were discussed in combination with reported cases.RESULTS:SAPHO patients whose main symptoms were painful swelling and inflammation of the mandible,with or without restriction of mouth opening,were similar to diffuse sclerosing osteomyelitis of the mandible.For such disease,conservative treatment was the main treatment,and surgical treatment was not recommended.CONCLUSIONS:SAPHO is a rare disease,especially on the mandible.We should enhance our understanding of SAPHO and master the diagnostic criteria to improve early diagnosis rate and reduce unnecessary operation.

关 键 词：SAPHO 下颌骨骨髓炎 临床表现 

分 类 号：R782.3[医药卫生—口腔医学]