肿瘤抑制因子ZHX2研究进展  

Research progress of tumor suppressor ZHX2

作　　者：岳学田 武专昌 马春红 YUE XueTian;WU ZhuanChang;MA ChunHong(Department of Immunology,School of Basic Medical Sciences,Shandong University,Jinan 250012,China)

机构地区：[1]山东大学基础医学院医学免疫学系,济南250012

出　　处：《中国科学：生命科学》2018年第11期1162-1169,共8页Scientia Sinica(Vitae)

基　　金：国家杰出青年科学基金(批准号:81425012);国家重点研发计划(批准号:2016YFE0127000);国家自然科学基金(批准号:91529305;81370527;81702647)资助

摘　　要：转录因子ZHX2 (zinc-finger and homeoboxes 2)是ZHX家族成员,是新近发现的肿瘤抑制因子. ZHX2通过抑制细胞增殖和迁移以及耐药相关基因表达抑制肝细胞肝癌等多种肿瘤的进展.最新研究报道, ZHX2通过促进NF-κB激活,促进肾细胞肾癌的发生,强烈提示ZHX2在不同肿瘤中发挥不同作用,值得深入研究.另外, ZHX2还参与病毒感染、代谢调节、发育及其他多种重要病理生理过程.本文主要综述ZHX2的结构特征及其在肿瘤等重要疾病中的作用和机制,并介绍ZHX2的表达调控机制,以期为ZHX2的深入研究和临床应用提供理论依据.As a member of the ZHX(Zinc finger and homeoboxes) family, ZHX2 works as a transcriptional factor and is a newly identified tumor suppressor. ZHX2 inhibits progression of hepatocellular carcinoma(HCC) and other types of tumor by transcriptional repression of genes related to cell proliferation, metastasis and chemoresistance. However, a study published in Science 2018 showed that ZHX2 promotes clear cell renal cell carcinoma through activation of NF-κB signaling. Therefore, ZHX2 may play different roles in different types of tumor. Furthermore, ZHX2 takes part in many of pathological and physiological processes, such as virus infection, metabolism regulation, and development. In this review, we introduce information of ZHX2 and its function in tumor and other human diseases. We also describe the recent progress in ZHX2 regulation.

关 键 词：ZHX2 肝癌 发育 病毒感染 代谢 转录调控 

分 类 号：R730.2[医药卫生—肿瘤]