不同年龄和性别健康查体人群生化参数和肿瘤标志物的临床分析  

The Clinical Analysis of Biochemical Indicators and Tumor Markers of Human with Different Age and Gender

作　　者：郭菲[1] 高艳玲 门莎莎[1] 张丽娜[1] 高艳红[1] GUO Fei;GAO Yan-ling;MEN Sha-sha;ZHANG Li-na;GAO Yan-hong(Medical Laboratory Center,Chinese PLA General Hospital,Beijing 100853,China;Institute of Military Cognitive and Brain Sciences ,Academy of Military Medical Sciences,Beijing 100850,China)

机构地区：[1]解放军总医院医学检验中心,北京100853 [2]军事医学研究院军事认知与脑科学研究所,北京100850

出　　处：《标记免疫分析与临床》2018年第11期1644-1649,共6页Labeled Immunoassays and Clinical Medicine

摘　　要：目的对804名查体人员生化参数和肿瘤标志物的临床特点进行分析。方法利用罗氏COBAS8000全自动生化分析仪和免疫分析仪分别对804名查体人员肝功、肾功、酶类等15项生化参数和癌胚抗原等5项肿瘤标志物进行检测并分析。结果按性别分组显示,ALT、AST、TBA、GGT、CR、UA、CK、CA125、CEA等参数均为男性显著高于女性(P<0.05),HDL、CA19-9为女性显著高于男性(P<0. 05)。异常率的统计分析结果显示,结果异常的参数主要集中在HDL(38.18%)、LDL(29.48%)、TG(28.36%)、GLU(12.60%)、GGT(12. 60%)等血脂、肝功和肾功类。在此基础上,进一步分析显示,TBA、GGT、GLU、BUN、CR、UA、CK、TG、CEA等参数的异常率均为男性显著高于女性,HDL、CA125、CA19-9的异常率为女性显著高于男性。将男性和女性分别按年龄段分成3组,39～49岁与50～55岁年龄段比较中,男性GIU差异显著,女性ALT、AST、TBA、ALP、GGT、BUN、UA、CH、TG、LDL、CK、LDH、AFP、CA125差异显著,50～55岁与≥56岁年龄段比较中,男性ALT、GGT、GLU、BUN、CH、TG、HDL、LDL、LDH、CEA、CA19-9差异显著,女性AST、BUN、CK、LDH、CEA差异显著。随着年龄增长,男性ALT、GGT、CH、AFP等的水平呈逐渐下降趋势,而GLU、BUN、LDH、CEA、CA153等的水平则呈逐渐上升趋势;女性CA125水平呈逐渐下降趋势,而ALT、AST、TBA、ALP、GGT、GLU、BUN、CR、UA、CH、TG、CK、LDH等的水平则呈逐渐上升趋势。结论查体人员中血糖、血脂、肝功类参数的异常最为常见,对于男性,其在血糖、肾功能和血脂代谢异常方面要更值得关注;男性在56岁以后多项参数开始呈现显著性变化,而女性在50岁左右这种差异就已经凸显,并且差异显著的参数数量要多于男性。Objective To explore the characteristics of biochemical indicators and tumor markers in different genders and ages.Methods The Roche COBAS 8000 automatic biochemical analyzer and immunoanalyzer were used to detect the biochemical indicators and tumor markers of 804 physical examination personnels and analyze the datas.Results ALT、AST、TBA、GGT、CR、UA、CK、CA125、CEA of male were higher than those of female.HDL and CA19-9 of female were higher than those of male.The abnormal results were mainly concentrated in HDL(38.18%),LDL(29.48%),TG(28.36%),GLU(12.60%)and GGT(12.60%).The abnormal rates of TBA,GGT,GLU,BUN,CR,UA,CK,TG and CEA of male were all significantly higher than those of female,and the abnormality rates of HDL,CA125 and CA19-9 of female were significantly higher than those of male.The men and women were divided into three groups according to age.In comparison between the ages of 39-49 and 50-55,male had significant differences in GLU,and female hadthe significant differences in ALT,AST,TBA,ALP,GGT,BUN,UA,CH,TG,LDL,CK,LDH,AFP and CA125.In comparison between the ages of 50-55 and ≥ 56,the significant differences indicators of male were ALT,GGT,GLU,BUN,CH,TG,HDL,LDL,LDH,CEA and CA19-9,and the significant differences of female were AST,BUN,CK,LDH and CEA.With the increase of age,the level of male ALT,GGT,CH,AFP decreased gradually,while the levels of GLU,BUN,LDH,CEA and CA153 showed a gradual upward trend. The level of female CA125 showed a gradual decline,while the indexes of ALT,AST,TBA,ALP,GGT, GLU,BUN,CR,UA,CH,TG,CK and LDH showed a gradual upward trend.Conclusion The abnormality of glucose,blood lipid and liver function is the most common among the physical examination personnel,and it is more important for men to pay more attention to their glucose,kidney function and abnormal blood lipid metabolism.After age 56,men begin to show significant changes in their biochemical indicators and tumor markers,the significant differences of women happen at about 50 years old,and the significant differenc

关 键 词：生化参数 肿瘤标志物 性别 年龄 健康体检 

分 类 号：R730.43[医药卫生—肿瘤]